• 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Molar mass255.317 g·mol−1
3D model (JSmol)
  • C1CNCC(C2=CC(=C(C=C21)O)O)C3=CC=CC=C3

SKF-38393 is a synthetic compound of the benzazepine chemical class which acts as a selective D1/D5 receptor partial agonist.[1] It has stimulant and anorectic effects.[2][3]

The trimethylation of SKF-38,393 leads to a named agent called Trepipam.

As with fenoldopam the inclusion of a chlorine halogen gave an agent that is called SKF-81,297.


  1. ^ Dubois A, Savasta M, Curet O, Scatton B (September 1986). "Autoradiographic distribution of the D1 agonist [3H]SKF 38393, in the rat brain and spinal cord. Comparison with the distribution of D2 dopamine receptors". Neuroscience. 19 (1): 125–37. doi:10.1016/0306-4522(86)90010-2. PMID 2946980. S2CID 19520384.
  2. ^ Trampus M, Ferri N, Adami M, Ongini E (April 1993). "The dopamine D1 receptor agonists, A68930 and SKF 38393, induce arousal and suppress REM sleep in the rat". European Journal of Pharmacology. 235 (1): 83–7. doi:10.1016/0014-2999(93)90823-Z. PMID 8100197.
  3. ^ Cooper SJ, Francis J, Rusk IN (1990). "The anorectic effect of SK&F 38393, a selective dopamine D1 receptor agonist: a microstructural analysis of feeding and related behaviour". Psychopharmacology. 100 (2): 182–7. doi:10.1007/BF02244403. PMID 1968277. S2CID 23977403.