SKF-91488
Names
Preferred IUPAC name
4-(Dimethylamino)butyl carbamimidothioate
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
DrugBank
UNII
  • InChI=1S/C7H17N3S/c1-10(2)5-3-4-6-11-7(8)9/h3-6H2,1-2H3,(H3,8,9)
    Key: UFYJLJINUGVUHO-UHFFFAOYSA-N
  • [H]/N=C(/N)\SCCCCN(C)C
Properties
C7H17N3S
Molar mass 175.29 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

SKF-91488 is a histamine N-methyltransferase inhibitor. It prevents the degradation of histamine, leading to increased histamine levels.[1][2]

See also

References

  1. ^ Thakkar, Mahesh M. (February 2011). "Histamine in the regulation of wakefulness". Sleep Medicine Reviews. 15 (1): 65–74. doi:10.1016/j.smrv.2010.06.004. PMC 3016451. PMID 20851648.
  2. ^ Tamaoki, J.; Chiyotani, A.; Tagaya, E.; Isono, K.; Konno, K. (1994). "Histamine N-methyltransferase Modulates Human Bronchial Smooth Muscle Contraction". Mediators of Inflammation. 3 (2): 125–129. doi:10.1155/S0962935194000153. PMC 2367027. PMID 18472930.