Solute carrier family 22 member 1 is a protein that in humans is encoded by the geneSLC22A1.[5][6]
Function
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.[6]
It is also required for the uptake of metformin by cells.[7][8]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Koehler MR, Wissinger B, Gorboulev V, Koepsell H, Schmid M (Jun 1998). "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26". Cytogenetics and Cell Genetics. 79 (3–4): 198–200. doi:10.1159/000134720. PMID9605850.
^Rosilio, C; Ben-Sahra, I; Bost, F; Peyron, JF (1 May 2014). "Metformin: a metabolic disruptor and anti-diabetic drug to target human leukemia". Cancer Letters. 346 (2): 188–96. doi:10.1016/j.canlet.2014.01.006. PMID24462823.
Liu YZ, Lania L, Latchman DS (October 1996). "Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor". AIDS. 10 (12): 1323–9. doi:10.1097/00002030-199610000-00003. PMID8902060. S2CID11659500.
Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM (June 1997). "Cloning and functional expression of a human liver organic cation transporter". Molecular Pharmacology. 51 (6): 913–21. doi:10.1124/mol.51.6.913. PMID9187257. S2CID30839969.
Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, Koepsell H (July 1997). "Cloning and characterization of two human polyspecific organic cation transporters". DNA and Cell Biology. 16 (7): 871–81. doi:10.1089/dna.1997.16.871. PMID9260930.
Verhaagh S, Schweifer N, Barlow DP, Zwart R (January 1999). "Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27". Genomics. 55 (2): 209–18. doi:10.1006/geno.1998.5639. PMID9933568.
Pan H, Qin WX, Huo KK, Wan DF, Yu Y, Xu ZG, Hu QD, Gu KT, Zhou XM, Jiang HQ, Zhang PP, Huang Y, Li YY, Gu JR (September 2001). "Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1". Genomics. 77 (1–2): 58–64. doi:10.1006/geno.2001.6614. PMID11543633.
Schinkel AH, Jonker JW (November 2002). "Polymorphisms affecting function of the human organic cation transporter hOCT1 (SLC22A1): what are the consequences?". Pharmacogenetics. 12 (8): 589–90. doi:10.1097/00008571-200211000-00001. PMID12439217.
Kerb R, Brinkmann U, Chatskaia N, Gorbunov D, Gorboulev V, Mornhinweg E, Keil A, Eichelbaum M, Koepsell H (November 2002). "Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences". Pharmacogenetics. 12 (8): 591–5. doi:10.1097/00008571-200211000-00002. PMID12439218.
