Protein-coding gene in the species Homo sapiens
Solute carrier family 2, facilitated glucose transporter member 9 is a protein that in humans is encoded by the SLC2A9 gene .[5] [6] [7]
This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene.[7]
SLC2A9 has also recently been found to transport uric acid , and genetic variants of the transporter have been linked to increased risk of development of both hyperuricemia , gout and Alzheimer's disease .[8] [9] [10]
Doege H, Bocianski A, Joost HG, Schürmann A (2001). "Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes" . Biochem. J . 350. Pt 3 (3): 771–6. doi :10.1042/0264-6021:3500771 . PMC 1221309 PMID 10970791 . Shikhman AR, Brinson DC, Valbracht J, Lotz MK (2001). "Cytokine regulation of facilitated glucose transport in human articular chondrocytes" . J. Immunol . 167 (12): 7001–8. doi :10.4049/jimmunol.167.12.7001 PMID 11739520 . Mobasheri A, Neama G, Bell S, et al. (2002). "Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9". Cell Biol. Int . 26 (3): 297–300. doi :10.1006/cbir.2001.0850 . PMID 11991658 . S2CID 34492031 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Richardson S, Neama G, Phillips T, et al. (2003). "Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation" . Osteoarthr. Cartil . 11 (2): 92–101. doi :10.1053/joca.2002.0858 PMID 12554125 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Augustin R, Carayannopoulos MO, Dowd LO, et al. (2004). "Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking" . J. Biol. Chem . 279 (16): 16229–36. doi :10.1074/jbc.M312226200 PMID 14739288 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . This article incorporates text from the United States National Library of Medicine , which is in the public domain .
By group
SLC1–10
(1): (2): (3): (4): (5): (6): (7): (8): (9): (10):
SLC11–20
(11):
proton coupled metal ion transporter
(12): (13):
human Na+ -sulfate/carboxylate cotransporter
(14): (15):
proton oligopeptide cotransporter
(16):
monocarboxylate transporter
(17): (18): (19): (20):
SLC21–30
(21): (22): (23):
Na+-dependent ascorbic acid transporter
(24): (25): (26):
multifunctional anion exchanger
(27): (28):
Na+ -coupled nucleoside transport (SLC28A1
(29):
facilitative nucleoside transporter
(30):
SLC31–40
(31): (32): (33): (34):
type II Na+ -phosphate cotransporter
(35):
nucleoside-sugar transporter
SLC35E1
SLC35E2
SLC35E3
SLC35E4 (36):
proton-coupled amino-acid transporter
(37):
sugar-phosphate/phosphate exchanger
(38):
System A & N, sodium-coupled neutral amino-acid transporter
(39): (40):
basolateral iron transporter
SLC41–48
(41): (42): (43):
Na+ -independent, system-L like amino-acid transporter
(44): (45):
Putative sugar transporter
(46): (47): (48):
