SOX13
Identifiers
Aliases	SOX13, ICA12, Sox-13, SRY-box 13, SRY-box transcription factor 13
External IDs	OMIM: 604748 MGI: 98361 HomoloGene: 4159 GeneCards: SOX13
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 204,073,115 bp[1] End 204,127,743 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 133,310,041 bp[2] End 133,352,115 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve right lung canal of the cervix popliteal artery left uterine tube right uterine tube upper lobe of left lung vagina subcutaneous adipose tissue gastric mucosa Top expressed in saccule otic placode intestinal villus lens lip pyloric antrum somite molar jejunum lung More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm Biological process anatomical structure morphogenesis regulation of transcription, DNA-templated transcription, DNA-templated regulation of gamma-delta T cell differentiation regulation of transcription by RNA polymerase II cell fate commitment negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9580 20668 Ensembl ENSG00000143842 ENSMUSG00000070643 UniProt Q9UN79 Q04891 RefSeq (mRNA) NM_005686 NM_011439 RefSeq (protein) NP_005677 NP_035569 Location (UCSC) Chr 1: 204.07 – 204.13 Mb Chr 1: 133.31 – 133.35 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor SOX-13 is a protein that in humans is encoded by the SOX13 gene.^[5][6]

Function

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12.^[6]

In melanocytic cells SOX13 gene expression may be regulated by MITF.^[7]