SP110
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1UFN
Identifiers
Aliases	SP110, IFI41, IFI75, IPR1, VODI, SP110 nuclear body protein
External IDs	OMIM: 604457 MGI: 3783243 HomoloGene: 82192 GeneCards: SP110
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 230,165,186 bp[1] End 230,225,729 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood lymph node spleen appendix sural nerve bone marrow cells thymus Achilles tendon gallbladder n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity metal ion binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated viral process signal transduction regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3431 101056250 Ensembl ENSG00000135899 n/a UniProt Q9HB58 n/a RefSeq (mRNA) NM_001185015 NM_004509 NM_004510 NM_080424 NM_001378442 NM_001378443 NM_001378444 NM_001378445 NM_001378446 NM_001378447 n/a RefSeq (protein) NP_001171944 NP_004500 NP_004501 NP_536349 NP_001365371 NP_001365372 NP_001365373 NP_001365374 NP_001365375 NP_001365376 n/a Location (UCSC) Chr 2: 230.17 – 230.23 Mb n/a PubMed search [2] [3]
Wikidata
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SP110 nuclear body protein is a protein that in humans is encoded by the SP110 gene.^[4][5][6]

The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified.^[6]