Protein-coding gene in the species Homo sapiens
SPG21 |
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Identifiers |
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Aliases | SPG21, ACP33, GL010, MAST, BM-019, spastic paraplegia 21 (autosomal recessive, Mast syndrome), maspardin, ABHD21, SPG21 abhydrolase domain containing, maspardin |
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External IDs | OMIM: 608181 MGI: 106403 HomoloGene: 9603 GeneCards: SPG21 |
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Wikidata |
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Maspardin is a protein that in humans is encoded by the SPG21 gene.[5][6][7]
The protein encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4.[7]
Interactions
SPG21 has been shown to interact with CD4.[5]