SPTBN5
Identifiers
Aliases	SPTBN5, BSPECV, HUBSPECV, HUSPECV, spectrin beta, non-erythrocytic 5
External IDs	OMIM: 605916 MGI: 2685200 HomoloGene: 41150 GeneCards: SPTBN5
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.1 Start 41,848,146 bp[1] End 41,894,053 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E5 Start 119,871,974 bp[2] End 119,916,159 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve cerebellar hemisphere retinal pigment epithelium skin of abdomen left ventricle right lobe of thyroid gland right lobe of liver trigeminal ganglion left lobe of thyroid gland minor salivary gland Top expressed in esophagus hypothalamus muscle tissue skeletal muscle tissue quadriceps femoris muscle lip zone of skin islet of Langerhans ovary white adipose tissue More reference expression data BioGPS n/a
Gene ontology Molecular function dynactin binding protein self-association kinesin binding myosin tail binding actin binding dynein intermediate chain binding spectrin binding Cellular component cytoplasm cytosol spectrin membrane photoreceptor connecting cilium photoreceptor disc membrane cytoskeleton microtubule organizing center filamentous actin Biological process Golgi organization MAPK cascade axon guidance endoplasmic reticulum to Golgi vesicle-mediated transport actin filament capping lysosomal transport protein homooligomerization actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51332 640524 Ensembl ENSG00000137877 ENSMUSG00000074899 UniProt Q9NRC6 n/a RefSeq (mRNA) NM_016642 NM_001370938 RefSeq (protein) NP_057726 n/a Location (UCSC) Chr 15: 41.85 – 41.89 Mb Chr 2: 119.87 – 119.92 Mb PubMed search [3] [4]
Wikidata
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Spectrin, beta, non-erythrocytic 5 also known as SPTBN5 is a protein that in humans is encoded by the SPTBN5 gene.^[5] SPTBN5 belongs to the spectrin family of cytoskeletal proteins.

Structure and function

SPTBN5 contains the following domains:^[5]

• actin-binding domain
• membrane-association domain-1
• self-association domain
• C-terminal pleckstrin homology domain.

Based on these structural features it is thought that SPTBN5 is likely to form heterodimers and oligomers with alpha-spectrin and to interact directly with cellular membranes.^[5]

SPTBN5 is highly expressed in embryoid bodies.^[6]