STX2
Identifiers
Aliases	STX2, EPIM, EPM, STX2A, STX2B, STX2C, syntaxin 2
External IDs	OMIM: 132350 MGI: 108059 HomoloGene: 37559 GeneCards: STX2
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.33 Start 130,789,600 bp[1] End 130,839,266 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G1.3|5 67.99 cM Start 129,061,621 bp[2] End 129,085,638 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte sural nerve right lung stromal cell of endometrium ganglionic eminence gastric mucosa right uterine tube bronchial epithelial cell Achilles tendon left coronary artery Top expressed in spermatid olfactory epithelium trigeminal ganglion internal carotid artery external carotid artery spermatocyte superior cervical ganglion bone marrow secondary oocyte sciatic nerve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein dimerization activity SNAP receptor activity calcium-dependent protein binding protein binding SNARE binding Cellular component integral component of membrane intracellular membrane-bounded organelle membrane synaptic vesicle plasma membrane basolateral plasma membrane SNARE complex lamellipodium extracellular space endomembrane system presynaptic membrane presynaptic active zone membrane Biological process cell differentiation ectoderm development synaptic vesicle fusion to presynaptic active zone membrane response to hydroperoxide acrosome reaction vesicle docking cornified envelope assembly protein complex oligomerization animal organ morphogenesis intracellular protein transport vesicle-mediated transport signal transduction exocytosis vesicle fusion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2054 13852 Ensembl ENSG00000111450 ENSMUSG00000029428 UniProt P32856 Q00262 RefSeq (mRNA) NM_001980 NM_194356 NM_001351049 NM_001351050 NM_001351051 NM_001351052 NM_001286033 NM_001286034 NM_007941 NM_001359022 RefSeq (protein) NP_001971 NP_919337 NP_001337978 NP_001337979 NP_001337980 NP_001337981 n/a Location (UCSC) Chr 12: 130.79 – 130.84 Mb Chr 5: 129.06 – 129.09 Mb PubMed search [3] [4]
Wikidata
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Syntaxin-2, also known as epimorphin, is a protein that in humans is encoded by the STX2 gene.^[5][6][7]

The product of this gene belongs to the syntaxin/epimorphin family of proteins. The syntaxins are a large protein family implicated in the targeting and fusion of intracellular transport vesicles. The product of this gene regulates epithelial-mesenchymal interactions and epithelial cell morphogenesis and activation. Alternatively spliced transcript variants encoding different isoforms have been identified.^[7] When the N terminus is on the cytosolic face it acts as a t-SNARE involved in intracellular vesicle docking and is called Syntaxin-2. When flipped inside out, i.e. N terminus hangs out on the extracellular surface (by some nonclassical secretion pathway) it acts as a versatile morphogen and is called epimorphin. This membrane protein enjoys the double choice of another form of topological alternatives of being targeted to either apical or basolateral surface of an epithelial cell in a regulated way depending on various contexts. When expressed by mesenchymal cells it can instruct epithelial morphogenesis at epithelial mesenchymal interfaces.

Interactions

STX2 has been shown to interact with SNAP-25,^[8][9] SNAP23,^{[9][10][11][12]} STXBP1^[8][13] and Syntaxin binding protein 3.^[13]