SYT3

Identifiers

SYT3, SytIII, synaptotagmin 3

External IDs

OMIM: 600327 MGI: 99665 HomoloGene: 9617 GeneCards: SYT3

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19q13.33	Start	50,621,307 bp^[1]
Band	19q13.33	End	50,639,881 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7 B3\|7 28.83 cM	Start	44,033,526 bp^[2]
Band	7 B3\|7 28.83 cM	End	44,049,611 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

superior frontal gyrus

prefrontal cortex

Brodmann area 9

hippocampus proper

hypothalamus

temporal lobe

amygdala

nucleus accumbens

putamen

caudate nucleus

Top expressed in

superior frontal gyrus

cerebellar cortex

entorhinal cortex

medulla oblongata

hippocampus proper

inferior colliculus

pons

superior colliculus

primary motor cortex

pontine nuclei

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	clathrin binding calcium ion binding metal ion binding calcium-dependent phospholipid binding syntaxin binding SNARE binding phosphatidylserine binding
Cellular component	integral component of membrane endosome transport vesicle membrane membrane cytoplasmic vesicle presynapse plasma membrane synapse exocytic vesicle
Biological process	positive regulation of dendrite extension cell differentiation calcium-ion regulated exocytosis calcium ion-regulated exocytosis of neurotransmitter regulation of calcium ion-dependent exocytosis vesicle fusion regulation of dopamine secretion synaptic vesicle exocytosis vesicle-mediated transport cellular response to calcium ion
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


84258


20981

Ensembl


ENSG00000213023


ENSMUSG00000030731

UniProt


Q9BQG1


O35681

RefSeq (mRNA)


NM_001160328 NM_001160329 NM_032298


NM_001114116 NM_016663

RefSeq (protein)

NP_001153800 NP_001153801 NP_115674 NP_001153800.1 NP_001153801.1
NP_115674.1


NP_001107588 NP_057872

Location (UCSC)

Chr 19: 50.62 – 50.64 Mb

Chr 7: 44.03 – 44.05 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Synaptotagmin-3 is a protein that in humans is encoded by the SYT3 gene.^[5]^[6]

References

Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC (June 1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature. 375 (6532): 594–9. Bibcode:1995Natur.375..594L. doi:10.1038/375594a0. PMID 7791877. S2CID 4265549.
Fukuda M, Kanno E, Mikoshiba K (October 1999). "Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X". The Journal of Biological Chemistry. 274 (44): 31421–7. doi:10.1074/jbc.274.44.31421. PMID 10531343.
Gerona RR, Larsen EC, Kowalchyk JA, Martin TF (March 2000). "The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes". The Journal of Biological Chemistry. 275 (9): 6328–36. doi:10.1074/jbc.275.9.6328. PMID 10692432.
Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Craxton M (September 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

v t e PDB gallery
1dqv: CRYSTAL STRUCTURE OF SYNAPTOTAGMIN III C2A/C2B

Membrane protein: vesicular transport proteins (TC 1F)

Synaptic vesicle

SNARE

Q-SNARE	SNAP25 SNAP29 Syntaxin STX1A STX1B STX2 STX3 STX4 STX5 STX6 STX7 STX8 STX10 STX11 STX12 STX16 STX17 STX18 STX19 Munc-18: STXBP1 STXBP2 STXBP3 STXBP4 STXBP5 STXBP6
R-SNARE	Synaptobrevin/VAMP: VAMP1 VAMP2 VAMP3

Synaptotagmin

SYT1
SYT2
SYT3
SYT4
SYT5
SYT6
SYT7
SYT8
SYT9
SYT10
SYT11
SYT12
SYT13
SYT14
SYT15
SYT16
SYT17

Other

Small GTPase: RAB3A

COPI

Coatomer
- COPA
- COPB1
- COPB2
- COPD/Archain
- COPE
- COPG
- COPG2
- COPZ1
- COPZ2

Small GTPase: ARF

COPII

Coatomer
- SEC23A/SEC24A
- SEC13/SEC31

Small GTPase: SAR1A

RME/Clathrin

CLTA
CLTB
CLTC

Caveolae

Other/ungrouped

Vesicle formation

Adaptor protein complex 1:	AP1AR AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3
Adaptor protein complex 2:	AP2A1 AP2A2 AP2B1 AP2M1 AP2S1
Adaptor protein complex 3:	AP3B1 AP3B2 AP3D1 AP3M1 AP3M2 AP3S1 AP3S2
Adaptor protein complex 4:	AP4B1 AP4E1 AP4M1 AP4S1
LMAN1
LYST
BLOC-1:	DTNBP1 BLOC153
BLOC-2:	HPS3 HPS5 HPS6
BLOC-3:	HPS1 HPS4
Coats:	Retromer TIP47

Small GTPase

Dynamin
- DNM1
- DNM2
- DNM3

Other

Sorting nexins

SYNRG

See also vesicular transport protein disorders

References

Further reading