SYT4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UGK
Identifiers
Aliases	SYT4, HsT1192, synaptotagmin 4
External IDs	OMIM: 600103 MGI: 101759 HomoloGene: 7559 GeneCards: SYT4
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q12.3 Start 43,267,892 bp[1] End 43,277,535 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18 B1|18 17.75 cM Start 31,570,861 bp[2] End 31,580,459 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis endothelial cell cerebellar hemisphere Brodmann area 23 Brodmann area 46 middle temporal gyrus superior frontal gyrus superior vestibular nucleus islet of Langerhans pons Top expressed in cerebellar vermis ventral tegmental area pineal gland dorsomedial hypothalamic nucleus habenula ventromedial nucleus paraventricular nucleus of hypothalamus lateral hypothalamus barrel cortex dorsal tegmental nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding clathrin binding phosphatidylserine binding metal ion binding protein binding SNARE binding syntaxin-1 binding syntaxin binding syntaxin-3 binding protein homodimerization activity protein heterodimerization activity calcium-dependent phospholipid binding Cellular component integral component of membrane intracellular membrane-bounded organelle membrane synapse synaptic vesicle membrane cell junction perinuclear region of cytoplasm neuron projection dense core granule cytoplasmic vesicle dendrite Golgi apparatus vesicle axon plasma membrane synaptic vesicle integral component of Golgi membrane integral component of synaptic vesicle membrane secretory granule membrane dense core granule membrane somatodendritic compartment neuronal cell body neuron projection terminus exocytic vesicle astrocyte projection microvesicle glutamatergic synapse integral component of neuronal dense core vesicle membrane Biological process cell differentiation brain development positive regulation of dendrite extension negative regulation of vesicle fusion neurotransmitter secretion exocytosis vesicle fusion calcium ion-regulated exocytosis of neurotransmitter memory positive regulation of glutamate secretion regulation of dopamine secretion regulation of endocytosis regulation of vesicle fusion negative regulation of catecholamine secretion positive regulation of calcium ion-dependent exocytosis negative regulation of neurotransmitter secretion negative regulation of short-term neuronal synaptic plasticity vesicle fusion with vesicle secretory granule maturation negative regulation of protein secretion negative regulation of retrograde trans-synaptic signaling by neuropeptide regulation of calcium ion-dependent exocytosis negative regulation of calcium ion-dependent exocytosis trans-synaptic signaling by BDNF, modulating synaptic transmission vesicle-mediated transport calcium-ion regulated exocytosis cellular response to calcium ion regulation of presynaptic dense core granule exocytosis negative regulation of dense core granule exocytosis positive regulation of dense core granule exocytosis negative regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6860 20983 Ensembl ENSG00000132872 ENSMUSG00000024261 UniProt Q9H2B2 P40749 RefSeq (mRNA) NM_020783 NM_009308 RefSeq (protein) NP_065834 NP_033334 Location (UCSC) Chr 18: 43.27 – 43.28 Mb Chr 18: 31.57 – 31.58 Mb PubMed search [3] [4]
Wikidata
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Synaptotagmin-4 is a protein that in humans is encoded by the SYT4 gene.^[5][6]