Salome Creek is a watercourse in the Salome Wilderness in central Arizona, United States.
The oldest exposed rock forms in the watershed are graphic granite, which dates to 1400 million years before present.[1] The watershed holds a diverse flora and fauna. Within this part of the Sierra Ancha range there are notable disjunctive populations of Coastal woodfern, Dryopteris arguta;[2] this fern is otherwise common in areas nearer the Pacific coast.