Samuel Caruthers (October 13, 1820 – July 20, 1860) was a U.S. Representative from Missouri.

Born in Madison County, Missouri, Caruthers graduated from Cumberland University, Lebanon, Tennessee. He studied law. He was admitted to the bar and commenced practice in Fredericktown, Missouri. He moved to Cape Girardeau, Missouri, in 1844. Congressman Caruthers held several local offices prior to being elected to the U.S. Congress.

Caruthers was elected as a Whig to the Thirty-third Congress. He was reelected as an Opposition Party candidate to the Thirty-fourth Congresses (March 4, 1853 – March 3, 1857). Caruthers changed political party membership again and was reelected as a Democrat to the Thirty-fifth Congress (March 4, 1857 – March 3, 1859). He died in Cape Girardeau, Missouri, July 20, 1860.

Caruthersville, Missouri, was named in his honor.^[1]