Samuel or Sam Cunningham may refer to:

Politics

• Samuel Cunningham (Canadian politician) (1848–1919), member of the Northwest Territories Legislative Assembly
• Samuel Cunningham (Northern Ireland politician) (1862–1946), Northern Irish businessman and politician
• Sir Knox Cunningham (Samuel Knox Cunningham, 1909–1976), Northern Irish barrister, businessman and politician, son of the above
• Sam Cunningham (mayor) (fl. 1975–2017), American politician, mayor of Waukegan, Illinois

Sports

• Sam Cunningham (1950–2021), American football player
• Samuel Cunningham (footballer) (born 1989), Thai footballer