Samuel Smith (Connecticut politician) (1646–1735), early settler of Norwalk, Connecticut and deputy of the General Assembly of the Colony of Connecticut in 1691
Samuel Smith (1754–1834), British Member of Parliament for Leicester, Malmesbury, Midhurst, St Germans and Wendover
Samuel Smith (1755–1793), British Member of Parliament for Worcester, Ludgershall and Ilchester
Samuel Smith (North Carolina), 18th-century North Carolina politician
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