Santino is an Italian masculine given name or nickname, meaning “little saint” in Italian. It is a diminutive version of the given name Santo, meaning “saint” or “holy”. Notable people with the name include:

• Santino Basaldella (born 2004), Argentine surfer
• Santino Ferrucci (born 1998), American race car driver
• Santino Fontana (born 1982), American actor
• Santino Garsi (1542–1604), Italian lutenist and composer
• Santino Marella (born 1974), ring name of WWE wrestler Anthony Carelli
• Santino Quaranta (born 1984), American soccer player
• Santino Rice (born 1974), American fashion designer
• Santino Solari (1576–1646), Swiss architect
• Santino Vera (born 2006), Argentine footballer
• Santino William Legan, American perpetrator of the Gilroy Garlic Festival shooting

Fictional characters

• Santino (The Vampire Chronicles), a fictional character in the Vampire Chronicles.
• Sonny Corleone, a fictional character in Mario Puzo's 1969 novel The Godfather and its 1972 film adaptation.
• Santino Guillermo (portrayed by Zaijian Jaranilla), a fictional character in the 2009–2010 ABS-CBN religious drama series May Bukas Pa.

Other

• Santino (chimpanzee), a chimpanzee first observed to have the cognitive skills for forward planning and killed while escaping his enclosure