Sauvagine
Identifiers
OrganismPhyllomedusa sauvagei
SymbolN/A
CAS number74434-59-6
UniProtP01144
Search for
StructuresSwiss-model
DomainsInterPro

Sauvagine is a neuropeptide from the corticotropin-releasing factor (CRF) family of peptides and is orthologous to the mammalian hormone, urocortin 1, and the teleost fish hormone, urotensin 1.[1] It is 40 amino acids in length,[2] and has the sequence XGPPISIDLSLELLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2, with a pyrrolidone carboxylic acid modification at the N-terminal and amidation of the C-terminal isoleucine residue. It was originally isolated from the skin of the frog Phyllomedusa sauvagii. Given its relation to other CRF-related peptides, it exerts similar physiological effects as corticotropin-releasing hormone.[3][4]

Sauvagine belongs to the corticotropin-releasing factor (CRF) family that also includes CRF, urocortin l/urotensin l, urocortin II and urocortin III.[5][1]

Interactions

Sauvagine has been shown to interact with corticotropin releasing factor receptors 1 and 2, and (as with other CRF-related peptides) is also bound by the corticotropin-releasing factor binding protein.[6]

References

  1. ^ a b Lovejoy DA, de Lannoy L (December 2013). "Evolution and phylogeny of the corticotropin-releasing factor (CRF) family of peptides: expansion and specialization in the vertebrates". Journal of Chemical Neuroanatomy. 54: 50–6. doi:10.1016/j.jchemneu.2013.09.006. PMID 24076419. S2CID 24576375.
  2. ^ Montecucchi PC, Henschen A (August 1981). "Amino acid composition and sequence analysis of sauvagine, a new active peptide from the skin of Phyllomedusa sauvagei". International Journal of Peptide and Protein Research. 18 (2): 113–20. doi:10.1111/j.1399-3011.1981.tb02047.x. PMID 7309372.
  3. ^ Falaschi P, D'Urso R, Negri L, Rocco A, Montecucchi PC, Henschen A, Melchiorri P, Erspamer V (August 1982). "Potent in vivo and in vitro prolactin inhibiting activity of sauvagine, a frog skin peptide". Endocrinology. 111 (2): 693–5. doi:10.1210/endo-111-2-693. PMID 7094889.
  4. ^ Brown MR, Fisher LA, Spiess J, Rivier J, Rivier C, Vale W (July 1982). "Comparison of the biologic actions of corticotropin-releasing factor and sauvagine". Regulatory Peptides. 4 (2): 107–14. doi:10.1016/0167-0115(82)90101-X. PMID 6289384. S2CID 22063430.
  5. ^ Fekete EM, Zorrilla EP (April 2007). "Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: ancient CRF paralogs". Frontiers in Neuroendocrinology. 28 (1): 1–27. doi:10.1016/j.yfrne.2006.09.002. PMC 2730896. PMID 17083971.
  6. ^ Jahn O, Eckart K, Sydow S, Hofmann BA, Spiess J (January 2001). "Pharmacological characterization of recombinant rat corticotropin releasing factor binding protein using different sauvagine analogs". Peptides. 22 (1): 47–56. doi:10.1016/S0196-9781(00)00356-9. PMID 11179597. S2CID 45722298.


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