The scruple (℈) is a small unit in the apothecaries' system,^{[1]} derived from the old Roman scrupulum (lit. 'small pebble') unit^{[2]} (scrupulus/scrupulum).

The scruple is 1⁄24 ounce, 1⁄3 dram, or 20 grains.^{[1]} It is therefore equal to 1.2959782 grams. The Roman scruple was somewhat smaller, around 1.14 g.

The fluid scruple is 1⁄24 fluid ounce, 1⁄3 fluid dram, 20 minims, or 1⁄4 teaspoon, or 1 saltspoon. It is therefore equal to 1.2323 milliliters in US customary system.

in imperial customary system equal 1,1839 ml .