The second-generation antidepressants are a class of antidepressants characterized primarily by the era of their introduction, approximately coinciding with the 1970s and 1980s, rather than by their chemical structure or by their pharmacological effect. As a consequence, there is some controversy over which treatments actually belong in this class.

The term "third generation antidepressant" is sometimes used to refer to newer antidepressants,^[1] from the 1990s and 2000s, often selective serotonin reuptake inhibitors (SSRIs) such as; fluoxetine (Prozac), paroxetine (Paxil) and sertraline (Zoloft), as well as some non-SSRI antidepressants such as mirtazapine, nefazodone, venlafaxine, duloxetine and reboxetine. However, this usage is not universal.

Examples

This list is not exhaustive, and different sources vary upon which items should be considered second-generation.

• Amineptine
• Amoxapine
• Bupropion
• Iprindole
• Maprotiline
• Medifoxamine
• Mianserin
• Nomifensine
• Tianeptine
• Trazodone
• Venlafaxine
• Viloxazine