The 22nd Secretariat of the Communist Party of the Soviet Union was elected by the 22nd Central Committee in the aftermath of the 22nd Congress.
| Name (birth–death) |
Took office | Left office | Duration | Note |
|---|---|---|---|---|
| Nikita Khrushchev (1894–1971) |
31 October 1961 | 14 October 1964 | 2 years, 349 days | Elected First Secretary at the 1st Plenary Session, and relieved of his duties at the 9th Plenary Session. |
| Leonid Brezhnev (1906–1982) |
21 June 1963 | 8 April 1966 | 4 years, 159 days | Elected to the Secretariat at the 5th Plenary Session, and was elected First Secretary at the 9th Plenary Session. |
| Yuri Andropov (1914–1984) |
23 November 1962 | 8 April 1966 | 3 years, 136 days | Elected at the 4th Plenary Session. |
| Pyotr Demichev (1918–2000) |
31 October 1961 | 8 April 1966 | 4 years, 159 days | — |
| Leonid Ilyichev (1906–1990) |
31 October 1961 | 26 March 1965 | 3 years, 146 days | Relieved of his duties at the 11th Plenary Session. |
| Ivan Kapitonov (1915–2002) |
6 December 1965 | 8 April 1966 | 123 days | Elected at the 13th Plenary Session. |
| Frol Kozlov (1908–1965) |
31 October 1961 | 16 November 1964 | 3 years, 16 days | Relieved of his duties at the 10th Plenary Session. |
| Fyodor Kulakov (1918–1978) |
29 September 1965 | 8 April 1966 | 191 days | Elected at the 12th Plenary Session. |
| Otto Wille Kuusinen (1881–1964) |
31 October 1961 | 17 May 1964 | 2 years, 199 days | — |
| Nikolai Podgorny (1903–1983) |
21 June 1963 | 6 December 1965 | 2 years, 168 days | Elected at the 5th Plenary Session, and relieved of his duties at the 13th Plenary Session. |
| Boris Ponomarev (1905–1995) |
31 October 1961 | 8 April 1966 | 4 years, 159 days | — |
| Vasily Polyakov (1913–2003) |
23 November 1962 | 16 November 1964 | 1 year, 328 days | Elected at the 4th Plenary Session, and relieved of his duties at the 10th Plenary Session. |
| Aleksandr Rudakov (1910–1966) |
23 November 1962 | 8 April 1966 | 3 years, 136 days | Elected at the 4th Plenary Session. |
| Alexander Shelepin (1918–1994) |
31 October 1961 | 8 April 1966 | 4 years, 159 days | — |
| Ivan Spiridonov (1905–1991) |
31 October 1961 | 23 April 1962 | 174 days | Relieved of his duties at the 3rd Plenary Session. |
| Mikhail Suslov (1902–1982) |
31 October 1961 | 8 April 1966 | 4 years, 159 days | — |
| Vitaly Titov (1907–1980) |
31 October 1961 | 29 September 1965 | 3 years, 333 days | Relieved of his duties at the 12th Plenary Session. |
| Dmitriy Ustinov (1908–1984) |
26 March 1965 | 8 April 1966 | 1 year, 13 days | Elected at the 11th Plenary Session. |