This article may require cleanup to meet Wikipedia's quality standards. The specific problem is: citations need to follow WP:MEDRS — some are incomplete, out-of-date or unreliable sources. Please help improve this article if you can. (December 2012) (Learn how and when to remove this message)
Separation anxiety disorder
SpecialtyPsychiatry

Separation anxiety disorder (SAD) is an anxiety disorder in which an individual experiences excessive anxiety regarding separation from home and/or from people to whom the individual has a strong emotional attachment (e.g., a parent, caregiver, significant other, or siblings). Separation anxiety is a natural part of the developmental process. It is most common in infants and little children, typically between the ages of six to seven months to three years, although it may pathologically manifest itself in older children, adolescents and adults. Unlike SAD (indicated by excessive anxiety), normal separation anxiety indicates healthy advancements in a child's cognitive maturation and should not be considered a developing behavioral problem.[1][2]

According to the American Psychiatric Association (APA), separation anxiety disorder is an excessive display of fear and distress when faced with situations of separation from the home and/or from a specific attachment figure. The anxiety that is expressed is categorized as being atypical of the expected developmental level and age.[3] The severity of the symptoms ranges from anticipatory uneasiness to full-blown anxiety about separation.[4]

SAD may cause significant negative effects within areas of social and emotional functioning, family life, and physical health of the disordered individual.[3] The duration of this problem must persist for at least four weeks and must present itself before a child is eighteen years of age to be diagnosed as SAD in children, but can now be diagnosed in adults with a duration typically lasting six months in adults as specified by the DSM-5.[5]

Background

The origins of separation anxiety disorder stem from attachment theory which has roots in the attachment theories both of Sigmund Freud and John Bowlby. Freud's attachment theory, which has similarities to learning theory, proposes that infants have instinctual impulses, and when these impulses go unnoticed, it traumatizes the infant.[6] The infant then learns that when their mother is absent, this will be followed by a distressing lack of gratification, thus making the mother's absence a conditioned stimulus that triggers anxiety in the infant who then expects their needs to be ignored.[7] The result of this association is that the child becomes fearful of all situations that include distance from their caregiver.

John Bowlby's attachment theory also contributed to the thinking process surrounding separation anxiety disorder. His theory is a framework in which to contextualize the relationships that humans form with one another. Bowlby suggests that infants are instinctively motivated to seek proximity with a familiar caregiver, especially when they are alarmed, and they expect that in these moments they will be met with emotional support and protection.[8] He poses that all infants become attached to their caregivers, however, there are individual differences in the way that these attachments develop. There are 4 main attachment styles according to Bowlby; secure attachment, anxious-avoidant attachment, disorganized attachment, and anxious-ambivalent attachment. Anxious-ambivalent attachment is most relevant here because its description, when an infant feels extreme distress and anxiety when their caregiver is absent and does not feel reassured when they return, is very similar to SAD.

Signs and symptoms

Academic setting

As with other anxiety disorders, children with SAD tend to face more obstacles at school than those without anxiety disorders. Adjustment and relating school functioning have been found to be much more difficult for anxious children.[9] In some severe forms of SAD, children may act disruptively in class or may refuse to attend school altogether. It is estimated that nearly 75% of children with SAD exhibit some form of school refusal behavior.[3]

There are several possible manifestations of this disorder when the child is introduced into an academic setting.[10] A child with SAD may protest profusely upon arrival at school. They might have a hard time saying goodbye to their parents and exhibit behaviors like tightly clinging to the parent in a way that makes it nearly impossible for the parent to detach from them. They might scream and cry but in a way that makes it seem as though they were in pain. The child might scream and cry for an extended period of time after his or her parents are gone (for several minutes to upwards of an hour) and refuse to interact with other children or teachers, rejecting their attention. They might feel an overwhelming need to know where their parents are and that they are okay.

This is a serious problem because, as children fall further behind in coursework, it becomes increasingly difficult for them to return to school.[11]

Short-term problems resulting from academic refusal include poor academic performance or decline in performance, alienation from peers, and conflict within the family.[3]

Although school refusal behavior is common among children with SAD, it is important to note that school refusal behavior is sometimes linked to generalized anxiety disorder or possibly a mood disorder.[12] That being said, a majority of children with separation anxiety disorder have school refusal as a symptom. Up to 80% of children who refuse school qualify for a diagnosis of separation anxiety disorder.[13]

Home setting

Symptoms for SAD might persist even in a familiar and/or comfortable setting for the child, like the home.[10] The child might be afraid to be in a room alone even if they know that their parent is in the next room over. They might fear being alone in the room, or going to sleep in a dark room. Problems might present themselves during bedtime, as the child might refuse to go to sleep unless their parent is near and visible. During the day, the child might "shadow" the parent and cling to their side.

Workplace

Just how SAD affects a child's attendance and participation in school, their avoidance behaviors stay with them as they grow and enter adulthood. Recently, "the effects of mental illness on workplace productivity have become a prominent concern on both the national and international fronts".[14] In general, mental illness is a common health problem among working adults, 20% to 30% of adults will suffer from at least one psychiatric disorder.[14] Mental illness is linked to decreased productivity, and with individuals diagnosed with SAD their levels at which they function decreases dramatically resulting in partial work-days, increase in number of total absences, and "holding back" when it comes to carrying out and completing tasks.[14][15]

Cause

Factors that contribute to the disorder include a combination and interaction of biological, cognitive, environmental, child temperament, and behavioral factors.

Children are more likely to develop SAD if one or both of their parents was diagnosed with a psychological disorder.[16] Recent research by Daniel Schechter and colleagues have pointed to difficulties of mothers who have themselves had early adverse experiences such as maltreatment and disturbed attachments with their own caregivers, who then go on to develop responses to their infants' and toddlers' normative social bids in the service of social referencing, emotion regulation, and joint attention, which responses are linked to these mothers own psychopathology (i.e. maternal post-traumatic stress disorder (PTSD) and depression.[17]) These atypical maternal responses, which have been shown to be associated with separation anxiety, have been related to disturbances in maternal stress physiologic response to mother-toddler separation, as well as lower maternal neural activity in the brain region of the medial prefrontal cortex, when mothers with and without PTSD were shown video excerpts of their own and unfamiliar toddlers during mother-child separation versus free-play.[18] Living in a low socioeconomic status (SES) has also been shown to contribute to childhood SAD by increasing levels of parental depression.[19]

Many psychological professionals have suggested that early or traumatic separation from a central caregiver in a child's life can increase the likelihood of them being diagnosed with SAD, school phobia, and depressive-spectrum disorders. Some children can be more vulnerable to SAD due to their temperament, for example, their level of anxiety when placed in new situations.[20][21]

Environmental

Most often, the onset of separation anxiety disorder is caused by a stressful life-event, especially a loss of a loved one or pet, but can also include parental divorce, change of school or neighborhood, natural disasters, or circumstances which forced the individual to be separated from their attachment figure(s). In older individuals, stressful life experiences may include going away to college, moving out for the first time, or becoming a parent.[22]

According to the DSM-5, young adults with separation anxiety disorder have different examples of stress, including leaving their parents' home, entering a romantic relationship, and becoming a parent. In some cases, parental overprotectiveness may be associated with separation anxiety disorder.

Genetic and physiological

There may be a genetic predisposition in children with separation anxiety disorder. "Separation anxiety disorder in children may be heritable."[23] "Heritability was estimated at 73% in a community sample of 6-year-old twins, with higher rates in girls."[24]

A child's temperament can also impact the development of SAD. Timid and shy behaviors may be referred to as "behaviorally inhibited temperaments" in which the child may experience anxiety when they are not familiar with a particular location or person.[25] Low levels of child effortful control and self-regulation, the abilities to regulate one’s emotional, sensory, and behavioral responses and impulses, have also been shown to contribute to the development of SAD.[19] Additionally, higher levels of child negative affect, or tendencies to display negative emotions and remain in such a state, also predict SAD.[19]

There are also unique genetic traits that may contribute to SAD development in adulthood. One study found that negative temperament predicted higher levels of adult separation anxiety.[26]

Mechanism

Preliminary evidence shows that heightened activity of the amygdala may be associated with symptoms of separation anxiety disorder. Defects in the ventrolateral and dorsomedial areas of the prefrontal cortex are also correlated to anxiety disorders in children.[27]

Diagnosis

Separation anxiety occurs in many infants and young children as they are becoming acclimated with their surroundings. This anxiety is viewed as a normal developmental phase between the months of early infancy until age two.[3] Separation anxiety is normal in young children, until they age 3–4 years, when children are left in a daycare or preschool, away from their parent or primary caregiver.[28] Other sources note that a definite diagnosis of SAD should not be presented until after the age of three.[25]

Some studies have shown that hormonal influences during pregnancy can result in lower cortisol levels later in life, which can later lead to psychological disorders, such as SAD. It is also important to note significant life changes experienced by the child either previous to or present at the onset of the disorder. For example, children who emigrated from another country at an early age may have a stronger tendency for developing this disorder, as they have already felt displaced from a location they were starting to become accustomed to. It is not uncommon for them to incessantly cling to their caregiver at first upon arrival to the new location, especially if the child is unfamiliar with the language of their new country.[29] These symptoms may diminish or go away as the child becomes more accustomed to the new surroundings. Separation anxiety may be diagnosed as a disorder if the child's anxiety related to separation from the home or attachment figure is deemed excessive; if the level of anxiety surpasses that of the acceptable caliber for the child's developmental level and age; and if the anxiety negatively impacts the child's everyday life.[3]

Many psychological disorders begin to emerge during childhood.[30] Nearly two-thirds of adults with psychological disorder show signs of their disorder earlier in life. However, not all psychological disorders are present before adulthood. In many cases, there are no signs during childhood.[31][32]

Behavioral inhibition (BI) plays a large role in many anxiety disorders, SAD included. Compared to children without it, children with BI demonstrate more signs of fear when experiencing a new stimulus, particularly those that are social in nature.[33] Children with BI are at a higher risk for developing a mental disorder, particularly anxiety disorders, than children without BI.[34]

To be diagnosed with SAD, one must display at least three of the following criteria:

[35]

Classification

Separation anxiety is common for infants between the ages of eight and fourteen months and occurs as infants begin to understand their own selfhood—or understand that they are separate persons from their primary caregiver. Infants oftentimes look for their caregivers to give them a sense of comfort and familiarity, which causes separation to become challenging.[36] Subsequently, the concept of object permanence emerges—which is when children learn that something still exists when it cannot be seen or heard, thus increasing their awareness of being separated from their caregiver. Consequently, during the developmental period where an infant's sense self, incorporating object permanence as well, the child also begins to understand that they can in fact be separated from their primary caregiver. They see this separation as something final though, and don't yet understand that their caregiver will return causing fear and distress for the infant. It is when an individual (infant, child, or otherwise) consistently reacts to separation with excessive anxiety and distress and experiences a great deal of interference from their anxiety that a diagnosis of separation anxiety disorder (SAD) can be warranted.[37]

One of the difficulties in the identification of separation anxiety disorder in children is that it is highly comorbid with other behavioral disorders, especially generalized anxiety disorder. Behaviors such as refusal or hesitancy in attending school or homesickness for example, can easily reflect similar symptoms and behavioral patterns that are commonly associated with SAD, but could be an overlap of symptoms. The prevalence of co-occurring disorders in adults with separation anxiety disorder is common and includes a much broader spectrum of diagnostic possibilities. Common co-morbidities can include specific phobias, PTSD, panic disorder, obsessive-compulsive disorder, and personality disorders.[38] It is very common for psychological disorders to overlap and even lead to the manifestation of another, especially when it comes to anxiety disorders. Because of the variation and overlap in symptoms a proper, thorough evaluation of the individual is critical to distinguish the differences and significance.[39] An important signifier to establish a difference between SAD and other anxiety or psychological disorders is to investigate where the individual's fear of separation is stemming from; this can be accomplished by asking "what they fear will occur during a separation from their significant other".[37]

What stands out about SAD, as mentioned above, are the avoidance behaviors which present within an individual. Individuals "typically exhibit excessive distress manifested by crying, repeated complaints of physical symptoms (e.g., stomach aches, headaches, etc.), avoidance (e.g., refusing to go to school, to sleep alone, to be left alone in the home, to engage in social events, to go to work, etc.), and engagement in safety behaviors (e.g., frequent calls to or from significant others, or primary caregivers)".[37]

Assessment methods

Assessment methods include diagnostic interviews, self-report measures from both the parent and child, observation of parent-child interaction, and specialized assessment for preschool-aged children. Various facets of a child's development including social life, feeding and sleep schedules, medical issues, traumatic events experienced, family history of mental or anxiety health issues are explored. The compilation of aspects of a child's life aids in capturing a multi-dimensional view of the child's life.[25]

Additionally, while much research has been done in efforts to further understand separation anxiety in regards to the relationship between infants' and their caregivers, it was behavioral psychologist, Mary Ainsworth, who devised a behavioral evaluation method, The Strange Situation (1969), which, at the time, was considered to be the most valuable and famous body of research in the study of separation anxiety. The Strange Situation process assisted in evaluating and measuring the individual attachment styles of infants between the ages of 9 and 18 months. In this observational study an environment is created that fluctuates between familiar and unfamiliar situations that would be experienced in everyday life. The variations in stressfulness and the child's responses are observed and, based on the interaction behavior that is directed towards the caregiver, the infant is categorized into one of four different types of attachment styles: 1. Secure, 2. Anxious-avoidant, insecure, 3. Anxious-ambivalent/resistant, insecure and 4. Disorganized/disoriented.[40]

Clinicians may utilize interviews as an assessment tool to gauge the symptomatic occurrences to aid in diagnosing SAD. Interviews may be conducted with the child and also with the attachment figure. Interviewing both child and parent separately allows for the clinician to compile different points of view and information.[3]

Commonly used interviews include:[3]

Self-report measures

This form of assessment should not be the sole basis of a SAD diagnosis. It is also important to verify that the child who is reporting on their experiences has the cognitive and communication skills appropriate to accurately comprehend and respond to these measurements.[3] An example of a self-report tool that has been tested is: The Separation Anxiety Assessment Scale for Children (SAAS-C). The scale contains 34 items and is divided into six dimensions. The dimensions in order are: Abandonment, Fear of Being Alone, Fear of Physical Illness, Worry about Calamitous Events, Frequency of Calamitous Events, and Safety Signal Index. The first five dimensions have a total of five items while the last one contains nine items. The scale goes beyond assessing symptoms; it focuses on individual cases and treatment planning.[41]

Observation

As noted by Altman, McGoey & Sommer, it is important to observe the child, "in multiple contexts, on numerous occasions, and in their everyday environments (home, daycare, preschool)".[25] It is beneficial to view parent and child interactions and behaviors that may contribute to SAD.[3]

Dyadic Parent-Child Interaction Coding System and recently the Dyadic Parent-Child Interaction Coding System II (DPICS II) are methods used when observing parents and children interactions.[42]

Separation Anxiety Daily Diaries (SADD) have also been used to "assess anxious behaviors along with their antecedents and consequences and may be particularly suited to SAD given its specific focus on parent–child separation" (Silverman & Ollendick, 2005). The diaries are carefully evaluated for validity.[43]

Preschool-aged children

At the preschool-aged stage, early identification and intervention is crucial.[3] The communication abilities of young children are taken into consideration when creating age-appropriate assessments.[25]

A commonly used assessment tool for preschool-aged children (ages 2–5) is the Preschool Age Psychiatric Assessment (PAPA).[3] Additional questionnaires and rating scales that are used to assess the younger population include the Achenbach Scales, the Fear Survey Schedule for Infants and Preschoolers, and The Infant–Preschool Scale for Inhibited Behaviors.[25]

Preschool children are also interviewed. Two interviews that are sometimes conducted are Attachment Doll-Play and Emotional Knowledge. In both of the assessments the interviewer depicts a scenario where separation and reunion occur; the child is then told to point at one of the four facial expressions presented. These facial expressions show emotions such as anger or sadness. The results are then analyzed.[44]

Behavioral observations are also utilized when assessing the younger population. Observations enable the clinician to view some of the behaviors and emotions in specific contexts.[25]

Treatment

Non-medication based

Non-medication based treatments are the first choice when treating individuals diagnosed with separation anxiety disorder.[4] Counseling tends to be the best replacement for drug treatments. There are two different non-medication approaches to treat separation anxiety. The first is a psychoeducational intervention, often used in conjunction with other therapeutic treatments.[4] This specifically involves educating the individual and their family so that they are knowledgeable about the disorder, as well as parent counseling and guiding teachers on how to help the child.[4][45] The second is a psychotherapeutic intervention when prior attempts are not effective. Psychotherapeutic interventions are more structured and include behavioral, cognitive-behavioral, contingency, psychodynamic psychotherapy, and family therapy.[4]

Anchors Away program for children with anxiety disorder

Exposure and behavioral therapy

Behavioral therapies are types of non-medication based treatment which are mainly exposure-based techniques. These include techniques such as systematic desensitization, emotive imagery, participant modelling and contingency management. Behavioral therapies carefully expose individuals by small increments to slowly reduce their anxiety over time and mainly focuses on their behavior.[46] Exposure based therapy works under the principle of habituation that is derived from learning theory. The core concept of exposure therapy is that anxiety about situations, people, and things does not go away when people avoid the things that they fear, but rather, the uncomfortable feelings are simply kept at bay. In order to effectively diminish the negative feelings associated with the situation of fear, one must address them directly. In order to administer this treatment, the therapist and the anxious child might sit together and identify progressively intense situations. As each situation is dealt with masterfully, the child advances to the next phase of intensity. This pattern continues until the child is able to handle being away from their parent in a developmentally typical way that causes them and their caregiver(s) minimal amounts of stress.[47] While there is some controversy about using exposure therapy with children,[48] it is generally agreed upon that exposure therapy in the context of SAD is acceptable as it may be the most effective form of therapy in treating this disorder and there is minimal risk associated with the intervention in this context.[49]

Contingency management

Contingency management is a form of treatment found to be effective for younger children with SAD. Contingency management revolves around a reward system with verbal or tangible reinforcement requiring parental involvement. A contingency contract is written up between the parent and the child, which entails a written agreement about specific goals that the child will try to achieve and the specific reward the parent will provide once the task is accomplished.[50] When the child undergoing contingency management shows signs of independence or achieves their treatment goals, they are praised or given their reward.[51] This facilitates a new positive experience with what used to be filled with fear and anxiety. Children in preschool who show symptoms of SAD do not have the communicative ability to express their emotions or the self-control ability to cope with their separation anxiety on their own, so parental involvement is crucial in younger cases of SAD.[4]

Cognitive behavioral therapy

Cognitive behavioral therapy (CBT) focuses on helping children with SAD reduce feelings of anxiety through practices of exposure to anxiety-inducing situations and active metacognition to reduce anxious thoughts.[3]

CBT has three phases: education, application and relapse prevention.[50] In the education phase, the individual is informed on the different effects anxiety can have physically and more importantly mentally. By understanding and being able to recognize their reactions, it will help to manage and eventually reduce their overall response.[50]

According to Kendall and colleagues, there are four components which must be taught to a child undergoing CBT:[52]

  1. Recognizing anxious feelings and behaviors
  2. Discussing situations that provoke anxious behaviors
  3. Developing a coping plan with appropriate reactions to situations
  4. Evaluating effectiveness of the coping plan

In the application phase, individuals can take what they know and apply it in real time situations for helpful exposure. The most important aspect of this phase is for the individuals to ultimately manage themselves throughout the process.[50] In the relapse prevention phase, the individual is informed that continued exposure and application of what worked for them is the key to continual progress.[50]

A study investigated the content of thoughts in anxious children who suffered from separation anxiety as well as from social phobia or generalized anxiety. The results suggested that cognitive therapy for children suffering from separation anxiety (along with social phobia and generalized anxiety) should be aimed at identifying negative cognition of one's own behavior in the threat of anxiety-evoking situations and to modify these thoughts to promote self-esteem and ability to properly cope with the given situation.[53]

Cognitive procedures are a form of treatment found to be ideal for older children with SAD.[4] The theory behind this technique is that the child's dysfunctional thoughts, attitudes, and beliefs are what leads to anxiety and causes anxious behavior.[4] Children who are being treated with cognitive procedures are taught to ask themselves if there is "evidence" to support their anxious thoughts and behaviors.[4] They are taught "coping thoughts" to replace previously distorted thoughts during anxiety-inducing situations such as doing a reality check to assess the realistic danger of a situation and then to praise themselves for handling the situation bravely.[4] Examples of such disordered thoughts include polarized thinking, overgeneralization, filtering (focusing on negative), jumping to conclusions, catastrophizing, emotional reasoning, labeling, "shoulds", and placing blame on self and others.[54] Sometimes therapists will involve parents and teach them behavioral tactics such as contingency management.[50]

Medication

The use of medication is applied in extreme cases of SAD when other treatment options have been utilized and failed.[4][52] However, it has been difficult to prove the benefits of drug treatment in patients with SAD because there have been many mixed results.[3] Despite all the studies and testings, there has yet to be a specific medication for SAD. Medication prescribed for adults from the Food and Drug Administration (FDA) are often used and have been reported to show positive results for children and adolescents with SAD.[55]

There are mixed results regarding the benefits of using tricyclic antidepressants (TCAs), which includes imipramine and clomipramine.[56] One study suggested that imipramine is helpful for children with "school phobia," who also had an underlying diagnosis of SAD. However, other studies have also shown that imipramine and clomipramine had the same effect of children who were treated with the medication and placebo.[56] The most promising medication is the use of selective serotonin reuptake inhibitors (SSRI) in adults and children.[55] Several studies have shown that patients treated with fluvoxamine were significantly better than those treated with placebo.[3] They showed decreasing anxiety symptoms with short-term and long-term use of the medication.[3]

Prognosis

Discomfort from separations in children from ages 8 to 14 months is normal. Children oftentimes get nervous or afraid of unfamiliar people and places but if the behavior still occurs after the age of six and if it lasts longer than four weeks, the child might have separation anxiety disorder.[57] About 4% of children have the disorder. Separation anxiety disorder is very treatable especially when caught early on with medication and behavioral therapies.[46] Helping children with separation anxiety to identify the circumstances that elicit their anxiety (upcoming separation events) is important. A child's ability to tolerate separations should gradually increase over time when he or she is gradually exposed to the feared events. Encouraging a child with separation anxiety disorder to feel competent and empowered, as well as to discuss feelings associated with anxiety-provoking events promotes recovery.

Children with separation anxiety disorder often respond negatively to perceived anxiety in their caretakers, in that parents and caregivers who also have anxiety disorders may unwittingly confirm a child's unrealistic fears that something terrible may happen if they are separated from each other. Thus, it is critical that parents and caretakers become aware of their own feelings and communicate a sense of safety and confidence about separation.[58]

Longitudinal effects

Several studies aim to understand the long-term mental health consequences of SAD.[59] SAD contributed to vulnerability and acted as a strong risk factor for developing other mental disorders in people aged 19–30. Specifically disorders including panic disorder and depressive disorders were more likely to occur.[59] Other sources also support the increased likelihood of displaying either of the two psychopathologies with previous history of childhood SAD.[5]

Studies show that children who have separation anxiety at younger ages have more complex fear acquisition. This means that there is likely an interplay between associative and non-associative processes concerning fear and anxiety later in life.

Beyond mental health outcomes, SAD has also been shown to impact other important areas of functioning as well.  For preschool children, high and persistent levels of separation anxiety were shown to predict worse academic achievement, poorer physical health, and higher internalizing symptoms throughout middle-childhood and early adolescence.[60]

Epidemiology

Anxiety disorders are the most common type of psychopathology to occur in today's youth, affecting from 5–25% of children worldwide.[3] Of these anxiety disorders, SAD accounts for a large proportion of diagnoses. SAD may account for up to 50% of the anxiety disorders as recorded in referrals for mental health treatment.[3] SAD is noted as one of the earliest-occurring of all anxiety disorders.[5] Adult separation anxiety disorder affects roughly 7% of adults, though it has also been shown to occur in between 23-42% of adults in clinical samples.[26] It has also been reported that the clinically anxious pediatric population are considerably larger. For example, according to Hammerness et al. (2008) SAD accounted for 49% of admissions.[61]

Research suggests that 4.1% of children will experience a clinical level of separation anxiety. Of that 4.1% it is calculated that nearly a third of all cases will persist into adulthood if left untreated.[3] Research continues to explore the implications that early dispositions of SAD in childhood may serve as risk factors for the development of mental disorders throughout adolescence and adulthood.[59]

It is presumed that a much higher percentage of children suffer from a small amount of separation anxiety, and are not actually diagnosed. Multiple studies have found higher rates of SAD in girls than in boys, and that paternal absence may increase the chances of SAD in girls.[62]

See also

References

  1. ^ Redlich R, Grotegerd D, Opel N, Kaufmann C, Zwitserlood P, Kugel H, et al. (February 2015). "Are you gonna leave me? Separation anxiety is associated with increased amygdala responsiveness and volume". Social Cognitive and Affective Neuroscience. 10 (2): 278–284. doi:10.1093/scan/nsu055. PMC 4321627. PMID 24752071.
  2. ^ Davidson, Tish. "Separation Anxiety." Gale Encyclopedia of Children's Health: Infancy through Adolescence. 2006. Retrieved October 6, 2014, from Encyclopedia.com
  3. ^ a b c d e f g h i j k l m n o p q r s Ehrenreich JT, Santucci LC, Weiner CL (January 2008). "Separation Anxiety Disorder in Youth: Phenomenology, Assessment, and Treatment". Psicologia Conductual. 16 (3): 389–412. doi:10.1901/jaba.2008.16-389 (inactive 31 January 2024). PMC 2788956. PMID 19966943.((cite journal)): CS1 maint: DOI inactive as of January 2024 (link)
  4. ^ a b c d e f g h i j k Masi G, Mucci M, Millepiedi S (2001). "Separation anxiety disorder in children and adolescents: epidemiology, diagnosis and management". CNS Drugs. 15 (2): 93–104. doi:10.2165/00023210-200115020-00002. PMID 11460893. S2CID 24167753.
  5. ^ a b c Beesdo K, Knappe S, Pine DS (September 2009). "Anxiety and anxiety disorders in children and adolescents: developmental issues and implications for DSM-V". The Psychiatric Clinics of North America. 32 (3): 483–524. doi:10.1016/j.psc.2009.06.002. PMC 3018839. PMID 19716988.
  6. ^ Klein DF (September 2002). "Historical aspects of anxiety". Dialogues in Clinical Neuroscience. 4 (3): 295–304. doi:10.31887/DCNS.2002.4.3/dklein. PMC 3181682. PMID 22033777.
  7. ^ Fonagy, P. (1999). Handbook of attachment: Theory, research, and clinical applications. US: The Guilford Press. pp. 595–624.
  8. ^ Saygin D, Tabib T, Bittar HE, Valenzi E, Sembrat J, Chan SY, et al. (1992). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary Circulation. 10 (1): 759–775. doi:10.1037/0012-1649.28.5.759. PMC 7052475. PMID 32166015.
  9. ^ Saygin D, Tabib T, Bittar HE, Valenzi E, Sembrat J, Chan SY, et al. (2010). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary Circulation. 10 (1): 106–121. doi:10.1080/02796015.2010.12087793. PMC 7052475. PMID 32166015. S2CID 140357101.
  10. ^ a b Child Mind Institute. "Separation Anxiety Disorder Basics". Child Mind Institute.
  11. ^ Saygin D, Tabib T, Bittar HE, Valenzi E, Sembrat J, Chan SY, et al. (April 2008). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary Circulation. 10 (1): 261–272. doi:10.1002/pits.20299. PMC 7052475. PMID 32166015.
  12. ^ Eisen, A., Sussman, J., Schmidt, T., Mason, L., Hausler, L., & Hasim, R. (2012). Separation Anxiety Disorder. In Handbook of Child and Adolescent Anxiety Disorders (2011 ed.). Springer.
  13. ^ Dryden-Edwards R (January 2014). Stöppler MC (ed.). "Separation Anxiety Disorder". Medicine Net. Retrieved 8 March 2015.
  14. ^ a b c Dewa CS, Lin E (July 2000). "Chronic physical illness, psychiatric disorder and disability in the workplace". Social Science & Medicine. 51 (1): 41–50. doi:10.1016/S0277-9536(99)00431-1. PMID 10817467.
  15. ^ "Anxiety Disorders: Why They Matter and What Employers Can Do". Center for Workplace Mental Health. Retrieved 20 October 2020.
  16. ^ Fox AS, Kalin NH (November 2014). "A translational neuroscience approach to understanding the development of social anxiety disorder and its pathophysiology". The American Journal of Psychiatry. 171 (11): 1162–1173. doi:10.1176/appi.ajp.2014.14040449. PMC 4342310. PMID 25157566.
  17. ^ Schechter DS, Willheim E (July 2009). "Disturbances of attachment and parental psychopathology in early childhood". Child and Adolescent Psychiatric Clinics of North America. 18 (3): 665–686. doi:10.1016/j.chc.2009.03.001. PMC 2690512. PMID 19486844.
  18. ^ Schechter DS, Moser DA, Paoloni-Giacobino A, Stenz L, Gex-Fabry M, Aue T, et al. (April 16, 2015). "Methylation of NR3C1 is related to maternal PTSD, parenting stress and maternal medial prefrontal cortical activity in response to child separation among mothers with histories of violence exposure". Frontiers in Psychology. 6: 690. doi:10.3389/fpsyg.2015.00690. PMC 4447998. PMID 26074844.
  19. ^ a b c Gouze KR, Hopkins J, Lavigne JV, Bryant FB (June 2022). "A Multi-level Longitudinal Model of Risk Factors for Generalized and Separation Anxiety Symptoms in a Community Sample of 6-year-olds". Child Psychiatry and Human Development. 53 (3): 405–417. doi:10.1007/s10578-021-01132-7. PMID 33590383. S2CID 231935975.
  20. ^ Egger HL, Costello EJ, Angold A (July 2003). "School refusal and psychiatric disorders: a community study". Journal of the American Academy of Child and Adolescent Psychiatry. 42 (7): 797–807. doi:10.1097/01.chi.0000046865.56865.79. PMID 12819439. S2CID 25115126.
  21. ^ Knollmann M, Knoll S, Reissner V, Metzelaars J, Hebebrand J (January 2010). "School avoidance from the point of view of child and adolescent psychiatry: symptomatology, development, course, and treatment". Deutsches Ärzteblatt International. 107 (4): 43–49. doi:10.3238/arztebl.2010.0043. PMC 2822958. PMID 20165699.
  22. ^ Diagnostic and Statistical Manual of Mental Disorders (DSM-V). Arlington, VA: American Psychiatric Association. 2013. doi:10.1176/appi.books.9780890425596.744053. Adults with separation anxiety may be invasive and overprotective of their friends and loved ones.
  23. ^ "Risk and Prognostic Factors of Separation Anxiety". Diagnostic and Statistical Manual of Mental Disorders (DSM-V). Arlington, VA: American Psychiatric Association. 2013. doi:10.1176/appi.books.9780890425596.744053.
  24. ^ Bolton D, Eley TC, O'Connor TG, Perrin S, Rabe-Hesketh S, Rijsdijk F, Smith P (March 2006). "Prevalence and genetic and environmental influences on anxiety disorders in 6-year-old twins". Psychological Medicine. 36 (3): 335–344. doi:10.1017/s0033291705006537. PMID 16288680. S2CID 44579250.
  25. ^ a b c d e f g Altman C, McGoey KE, Sommer JL (2009). "Anxiety in early childhood: what do we know?". Journal of Early Childhood and Infant Psychology.
  26. ^ a b Finsaas MC, Klein DN (August 2021). "Adult separation anxiety: Personality characteristics of a neglected clinical syndrome". Journal of Abnormal Psychology. 130 (6): 620–626. doi:10.1037/abn0000682. PMC 8478136. PMID 34553957.
  27. ^ Blackford JU, Pine DS (July 2012). "Neural substrates of childhood anxiety disorders: a review of neuroimaging findings". Child and Adolescent Psychiatric Clinics of North America. 21 (3): 501–525. doi:10.1016/j.chc.2012.05.002. PMC 3489468. PMID 22800991.
  28. ^ Bagnell AL (October 2011). "Anxiety and separation disorders". Pediatrics in Review. 32 (10): 440–5, quiz 446. doi:10.1542/pir.32-10-440. PMID 21965711.
  29. ^ Robjant K, Hassan R, Katona C (April 2009). "Mental health implications of detaining asylum seekers: systematic review". The British Journal of Psychiatry. 194 (4): 306–312. doi:10.1192/bjp.bp.108.053223. PMID 19336779.
  30. ^ Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE (June 2005). "Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication". Archives of General Psychiatry. 62 (6): 593–602. doi:10.1001/archpsyc.62.6.593. PMID 15939837.
  31. ^ Copeland WE, Shanahan L, Costello EJ, Angold A (July 2009). "Childhood and adolescent psychiatric disorders as predictors of young adult disorders". Archives of General Psychiatry. 66 (7): 764–772. doi:10.1001/archgenpsychiatry.2009.85. PMC 2891142. PMID 19581568.
  32. ^ Pine DS, Cohen P, Gurley D, Brook J, Ma Y. 1998. The risk for early-adulthood anxiety and depressive disorders in adolescents with anxiety and depressive disorders. Arch. Gen. Psychiatry
  33. ^ Fox NA, Henderson HA, Marshall PJ, Nichols KE, Ghera MM (2005). "Behavioral inhibition: linking biology and behavior within a developmental framework". Annual Review of Psychology. 56: 235–262. doi:10.1146/annurev.psych.55.090902.141532. PMID 15709935. S2CID 5693529.
  34. ^ Clauss JA, Blackford JU (October 2012). "Behavioral inhibition and risk for developing social anxiety disorder: a meta-analytic study". Journal of the American Academy of Child and Adolescent Psychiatry. 51 (10): 1066–1075.e1. doi:10.1016/j.jaac.2012.08.002. PMC 3611590. PMID 23021481.
  35. ^ American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders: DSM-5. Washington, D.C: American Psychiatric Association.
  36. ^ Feigelman S. The first year. In: Kliegman RM, Stanton BF, St. Geme JW III, et al., eds. Nelson Textbook of Pediatrics, 19th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 8
  37. ^ a b c Jurbergs N, Ledley DR (February 2005). "Separation anxiety disorder". Pediatric Annals. 34 (2): 108–115. doi:10.3928/0090-4481-20050201-09. PMID 15768687.
  38. ^ "Comorbidity of Separation Anxiety.". Diagnostic and Statistical Manual of Mental Disorders (DSM-V). Arlington, VA: American Psychiatric Association. 2013. doi:10.1176/appi.books.9780890425596.744053.
  39. ^ Eisen A, Sussman, J, Schmidt T, Mason L, Hausler L, Hasim R (2011). "Separation Anxiety Disorder". In McKay D, Storch EA (eds.). Handbook of Child and Adolescent Anxiety Disorders. Springer.
  40. ^ Ainsworth M. "Attachment Styles". Simply Psychology. Retrieved 27 November 2014.
  41. ^ Chessa D, Di Riso D, Delvecchio E, Lis A (December 2012). "Assessing separation anxiety in Italian youth: preliminary psychometric properties of the Separation Anxiety Assessment Scale". Perceptual and Motor Skills. 115 (3): 811–832. doi:10.2466/03.10.15.PMS.115.6.811-832. PMID 23409595. S2CID 8775922.
  42. ^ Saygin D, Tabib T, Bittar HE, Valenzi E, Sembrat J, Chan SY, et al. (2011). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary Circulation. 10 (1): 187–195. doi:10.1007/s10862-011-9229-6. PMC 7052475. PMID 32166015. S2CID 59371757.
  43. ^ Allen JL, Blatter-Meunier J, Ursprung A, Schneider S (2010). "Maternal daily diary report in the assessment of childhood separation anxiety". Journal of Clinical Child and Adolescent Psychology. 39 (2): 252–259. doi:10.1080/15374410903532619. PMID 20390816. S2CID 37313065.
  44. ^ Saygin D, Tabib T, Bittar HE, Valenzi E, Sembrat J, Chan SY, et al. (2007). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary Circulation. 10 (1): 455–475. doi:10.1007/s10560-007-0095-8. PMC 7052475. PMID 32166015. S2CID 144247888.
  45. ^ Dryden-Edwards R (26 February 2021). Stöppler MS (ed.). "What Is Separation Anxiety? Treatment, Symptoms". MedicineNet.
  46. ^ a b "Separation Anxiety Disorder Basics". Child Mind Institute.
  47. ^ Hagopian LP, Slifer KJ (1993). "Treatment of separation anxiety disorder with graduated exposure and reinforcement targeting school attendance: A controlled case study". Journal of Anxiety Disorders. 7 (3): 271–280. doi:10.1016/0887-6185(93)90007-8.
  48. ^ Gola JA, Beidas RS, Antinoro-Burke D, Kratz HE, Fingerhut R (May 2016). "Ethical Considerations in Exposure Therapy With Children". Cognitive and Behavioral Practice. 23 (2): 184–193. doi:10.1016/j.cbpra.2015.04.003. PMC 5036521. PMID 27688681.
  49. ^ Jacofsky M, Santos MT, Khemlani-Patel S, Neziroglu F (20 March 2019). "Treatment For Separation Anxiety Disorder". Mental Help.
  50. ^ a b c d e f Silverman WK (September 2003). "Using CBT in the Treatment of Social Phobia, Separation Anxiety and GAD". Psychiatric Times. Psychiatric Times Vol 20 No 9. 20 (9). Retrieved 10 December 2014.
  51. ^ Saygin D, Tabib T, Bittar HE, Valenzi E, Sembrat J, Chan SY, et al. (1 July 2003). "Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension". Pulmonary Circulation. 10 (1): 188–198. doi:10.1177/1534650103002003002. PMC 7052475. PMID 32166015. S2CID 144996704.
  52. ^ a b Barrett PM, Ollendick TH, eds. (2003). Handbook of Interventions that Work with Children and Adolescents: Prevention and Treatment. Wiley. ISBN 978-0470844533.
  53. ^ Bögels SM, Zigterman D (April 2000). "Dysfunctional cognitions in children with social phobia, separation anxiety disorder, and generalized anxiety disorder". Journal of Abnormal Child Psychology. 28 (2): 205–211. doi:10.1023/A:1005179032470. PMID 10834771. S2CID 7670868.
  54. ^ Burns DD (1993). Ten Days to Self Esteem. William Morrow and Company Inc.
  55. ^ a b Suveg C, Aschenbrand SG, Kendall PC (October 2005). "Separation anxiety disorder, panic disorder, and school refusal". Child and Adolescent Psychiatric Clinics of North America. 14 (4): 773–95, ix. doi:10.1016/j.chc.2005.05.005. PMID 16171702.
  56. ^ a b Waslick B (January 2006). "Psychopharmacology interventions for pediatric anxiety disorders: a research update". Child and Adolescent Psychiatric Clinics of North America. 15 (1): 51–71. doi:10.1016/j.chc.2005.08.009. PMID 16321725.
  57. ^ "Separation Anxiety Disorder in Children". WebMD.
  58. ^ Feriante J, Bernstein B (2020). Perlstein D (ed.). "Separation Anxiety". WebMD. PMID 32809628.
  59. ^ a b c Lewinsohn PM, Holm-Denoma JM, Small JW, Seeley JR, Joiner TE (May 2008). "Separation anxiety disorder in childhood as a risk factor for future mental illness". Journal of the American Academy of Child and Adolescent Psychiatry. 47 (5): 548–555. doi:10.1097/CHI.0b013e31816765e7. PMC 2732357. PMID 18356763.
  60. ^ Battaglia M, Garon-Carrier G, Côté SM, Dionne G, Touchette E, Vitaro F, et al. (October 2017). "Early childhood trajectories of separation anxiety: Bearing on mental health, academic achievement, and physical health from mid-childhood to preadolescence" (PDF). Depression and Anxiety. 34 (10): 918–927. doi:10.1002/da.22674. PMID 28833904. S2CID 5314979.
  61. ^ Hammerness P, Harpold T, Petty C, Menard C, Zar-Kessler C, Biederman J (January 2008). "Characterizing non-OCD anxiety disorders in psychiatrically referred children and adolescents". Journal of Affective Disorders. 105 (1–3): 213–219. doi:10.1016/j.jad.2007.05.012. PMID 17572506.
  62. ^ Cohen P, Cohen J, Kasen S, Velez CN, Hartmark C, Johnson J, et al. (September 1993). "An epidemiological study of disorders in late childhood and adolescence--I. Age- and gender-specific prevalence". Journal of Child Psychology and Psychiatry, and Allied Disciplines. 34 (6): 851–867. doi:10.1111/j.1469-7610.1993.tb01094.x. PMID 8408371.
Categories