Serotonergic (/ˌsɛrətəˈnɜːrɪk, ˌsɪər-/[1][2]) or serotoninergic (/ˌsɪərətnɪˈnɜːrɪk/[3]) means "pertaining to or affecting serotonin". Serotonin is a neurotransmitter. A synapse is serotonergic if it uses serotonin as its neurotransmitter.[4] A serotonergic neuron produces serotonin.[5] A substance is serotonergic if it produces its effects via interactions with the serotonin system, such as by stimulating or blocking neurotransmission.

A serotonergic or serotoninergic agent is any chemical that modifies the effects of serotonin in the body.[6] Some different types of serotonergics drugs include the following:

See also


  1. ^ "Serotonergic". Merriam-Webster Dictionary.
  2. ^ "Serotonergic". Unabridged (Online). n.d.
  3. ^ "serotoninergic". Merriam-Webster Dictionary.
  4. ^ Kuffler, Damien P.; Nicholls, John; Drapeau, Pierre (1987). "Transmitter localization and vesicle turnover at a serotoninergic synapse between identified leech neurons in culture". The Journal of Comparative Neurology. 256 (4): 516–526. doi:10.1002/cne.902560404. PMID 2435767. S2CID 26853629.
  5. ^ Cohen, Jeremiah Y.; Amoroso, Mackenzie W.; Uchida, Naoshige (2015). "Serotonergic neurons signal reward and punishment on numerous timescales". eLife. 4. doi:10.7554/eLife.06346. PMC 4389268. PMID 25714923.
  6. ^ Koury, K. M.; Tsui, B.; Gulur, P. (2015). "Incidence of serotonin syndrome in patients treated with fentanyl on serotonergic agents". Pain Physician. 18 (1): E27-30. PMID 25675067.