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Seton is the surname of a prominent Scottish Lowlands family, Clan Seton, and may refer to:

Hereditary titles

• The Earls of Winton
• The Earls of Huntly
• The Earls of Dunfermline
• The Earls of Eglinton
• The Viscounts Kingston
• The Baronet of Windygoul
• The Baronets of Abercorn
• The Baronets of Garleton
• The Baronets of Pitmedden

Given names of several Setons

• Alexander Seton (disambiguation)
• George Seton (disambiguation)
• John Seton (disambiguation)

Other

• Alex Seton (born 1977), Australian artist
• Anya Seton (1906–1990), American historical novelist, daughter of Ernest Thompson Seton
• Archibald Seton (1758–1818), Scottish East India Company colonial administrator, resident, and civil servant
• Barry Seton (born 1936), Australian racing driver
• Bruce Seton (1909–1969), British actor and soldier
• Catherine Seton (1800–1891), daughter of Elizabeth Ann Seton
• Christopher Seton (died 1306), 13th-century Scottish noble
• Cora Seton (born 1969), author
• Cynthia Propper Seton (1926–1982), American novelist
• Elizabeth Ann Seton (1774–1821), American Catholic saint
• Ernest Thompson Seton (1860–1946), Canadian-American scouting pioneer
• George Seton (1822–1908), Scottish philanthropist and genealogist
• Glenn Seton (born 1965), Australian racing driver, son of Barry Seton
• James Alexander Seton (1816–1845), last British person to be killed in a duel on English soil
• John de Seton (died 1306), Scottish knight
• Josiah Seton (born 1979), Liberian footballer
• Maria Seton, Australian geologist
• Marie Seton (1910–1985), film critic and biographer
• Mary Seton (1549–1615), daughter of George Seton, 6th Lord Seton, one of the "Four Marys" of Mary, Queen of Scots
• Robert Seton (1839–1927), Monsignor, American Catholic Archbishop and historian
• Thomas Seton (c.1738–1806), Scottish painter
• William Seton (writer) (1835–1905), American author, novelist and popular science writer
• William Seton, 1st Lord Seton (died 1410), Scottish noble
• William Seton of Kylesmure (1562–1635), Scottish landowner and postmaster