Simple columnar epithelium is a single layer of columnar epithelial cells which are tall and slender with oval-shaped nuclei located in the basal region, attached to the basement membrane. In humans, simple columnar epithelium lines most organs of the digestive tract including the stomach, and intestines. Simple columnar epithelium also lines the uterus.
Simple columnar epithelium is further divided into two categories: ciliated and non-ciliated (glandular). The ciliated part of the simple columnar epithelium has tiny hairs which help move mucus and other substances up the respiratory tract.
The shape of the simple columnar epithelium cells are tall and narrow giving a column like appearance. the apical surfaces of the tissue face the lumen of organs while the basal side faces the basement membrane.[1] The nuclei are located closer along the basal side of the cell.[1]
Absorptive columnar epithelium is characterized as having a striated border on its apical side, this border is made up of non-motile microvilli allowing for increase surface area for absorption.[1] These are known as non-ciliated columnar epithelium. Non-ciliated simple columnar epithelium is made up of glandular goblet cells which secrete mucin to form mucus.[1] The rest of the cell is made up of cytoplasm with membrane bound secretory granules which secrete the mucin, and are found towards the apical surface of the cell.[1]
