Sisters of the Destitute (S. D.) is a Syro-Malabar Catholic women's religious institute.
The Congregation of the Sisters of the Destitute was founded by Venerable Mar Varghese Payyappilly Palakkappilly in Chunangamvely, Kerala on 19 March 1927.
It includes over 1,500 nuns and is composed of physicians, nurses, lawyers, teachers and social workers. Now it is working in Asia, Europe, Africa and the USA. One of the branch in Kayakkunn near Panamaram, Wayanad District.
Sisters of the Destitute runs many institutions like :