Smither is a surname. People so named include:

• Bob Smither (born 1944), Libertarian Party Texas congressional candidate
• Chris Smither (born 1944), American folk-blues singer, guitarist, and songwriter
• Denise Orme, stage name of Jessie Smither (1885–1960), English music hall singer, actress and musician
• Elizabeth Smither (born 1941), New Zealand poet and writer
• Henry Smither (1873–?), US Army officer and football coach
• James Smither FRIBA (1833–1910), Irish architect and Ceylonese public servant
• Michael Smither (born 1939), New Zealand painter and composer, husband of Elizabeth Smither

Fictional characters

• Dale Smither, from the television series Heroes