Sodium calcium edetate
Clinical data
Trade namesCalcium disodium versenate, others
Other namescalcium disodium EDTA, edetate calcium disodium, sodium calcium edetate
AHFS/Drugs.comMonograph
Routes of
administration		IV, IM
Drug classchelating agent
ATC code
Legal status
Legal status
Identifiers
  • Calcium disodium 2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEBI
E numberE385 (antioxidants, ...) Edit this at Wikidata
CompTox Dashboard (EPA)
ECHA InfoCard100.000.482 Edit this at Wikidata
Chemical and physical data
FormulaC10H12CaN2Na2O8
Molar mass374.270 g·mol−1
3D model (JSmol)
  • C(CN(CC(=O)[O-])CC(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Ca+2]
  • InChI=1S/C10H16N2O8.Ca.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;/q;+2;2*+1/p-4
  • Key:SHWNNYZBHZIQQV-UHFFFAOYSA-J

Sodium calcium edetate (sodium calcium EDTA), also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning,[2] including both short-term and long-term lead poisoning.[3] Sodium calcium edetate came into medical use in the United States in 1953.[3]

Chelation agent

Sodium calcium edetate is in the chelating agent family of medication.[3] It is a salt of edetate with two sodium and one calcium atoms.[4] It works by binding to a number of heavy metals, which renders them almost inert and allows them to leave the body in the urine.[3]

Edetate disodium (Endrate) is a different formulation which does not have the same effects.[3]

Medical use

Sodium calcium edetate's primary use is to treat lead poisoning,[2] for which it is an alternative to succimer.[3] It is given by slow injection into a vein or into a muscle.[2]

For lead encephalopathy sodium calcium edetate is typically used together with dimercaprol.[3] It may also be used to treat plutonium poisoning.[5] It does not appear to be useful for poisoning by tetra-ethyl lead.[3]

Side effects

Common side effects include pain at the site of injection.[3] Other side effects may include kidney problems, diarrhea, fever, muscle pains, and low blood pressure.[2] Benefits when needed in pregnancy are likely greater than the risks.[3]

History

Sodium calcium edetate came into medical use in the United States in 1953.[3] It is on the World Health Organization's List of Essential Medicines.[6]

References

  1. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
  2. ^ a b c d Stuart MC, Kouimtzi M, Hill SR, eds. (2009). WHO Model Formulary 2008. World Health Organization. pp. 59, 62, 65. hdl:10665/44053. ISBN 9789241547659.
  3. ^ a b c d e f g h i j k "Edetate Calcium Disodium". The American Society of Health-System Pharmacists. Archived from the original on 16 January 2017. Retrieved 8 January 2017.
  4. ^ Kasture AV (2008). Pharmaceutical Chemistry. Vol. I. Pragati Books Pvt. Ltd. p. 16.11. ISBN 9788185790121. Archived from the original on 16 January 2017.
  5. ^ Flanagan R, Jones A, Maynard RL (2003). Antidotes: Principles and Clinical Applications. CRC Press. p. 47. ISBN 9780203485071. Archived from the original on 16 January 2017.
  6. ^ Organization WH (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva,CH: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
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