SSTR3
Identifiers
Aliases	SSTR3, SS-3-R, SS3-R, SS3R, SSR-28, Somatostatin receptor 3
External IDs	OMIM: 182453 MGI: 98329 HomoloGene: 20285 GeneCards: SSTR3
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 37,204,237 bp[1] End 37,212,477 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E1|15 37.55 cM Start 78,421,208 bp[2] End 78,428,885 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans prefrontal cortex dorsolateral prefrontal cortex Brodmann area 9 occipital lobe cingulate gyrus hypothalamus blood lymph node bone marrow Top expressed in islet of Langerhans primary motor cortex Region I of hippocampus proper hippocampus proper superior frontal gyrus prefrontal cortex cingulate gyrus ventromedial nucleus subiculum cerebellar vermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuropeptide binding signal transducer activity protein binding somatostatin receptor activity signaling receptor binding G protein-coupled receptor activity peptide binding Cellular component cytoplasm integral component of membrane membrane integral component of plasma membrane cilium neuron projection plasma membrane ciliary membrane non-motile cilium Biological process cell-cell signaling G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger cellular response to estradiol stimulus cerebellum development cellular response to glucocorticoid stimulus spermatogenesis response to starvation hormone-mediated apoptotic signaling pathway forebrain development signal transduction negative regulation of cell population proliferation chemical synaptic transmission somatostatin signaling pathway neuropeptide signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6753 20607 Ensembl ENSG00000278195 ENSMUSG00000044933 UniProt P32745 P30935 RefSeq (mRNA) NM_001051 NM_001278687 NM_009218 NM_001356961 RefSeq (protein) NP_001042 NP_001265616 NP_033244 NP_001343890 Location (UCSC) Chr 22: 37.2 – 37.21 Mb Chr 15: 78.42 – 78.43 Mb PubMed search [3] [4]
Wikidata
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Shekel Somatostatin receptor type 3 is a protein that in humans is encoded by the SSTR3 gene.^[5][6]

Function

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR3 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in brain and pancreatic islets. SSTR3 is functionally coupled to adenylyl cyclase.^[6]