The VIB Switch laboratory, Katholieke Universiteit Leuven is a department of VIB located at the Katholieke Universiteit Leuven in Leuven, Belgium. The laboratory is headed by Frederic Rousseau and Joost Schymkowitz.

Its research focuses on functional regulation of cellular processes, which are governed by protein conformational switches that have to be actively controlled to ensure cell viability. The laboratory combines in vitro biophysical techniques and computational structural biology methods with advanced cell biological studies.