STX3
Identifiers
AliasesSTX3, STX3A, Syntaxin 3, MVID2, RDMVID, DIAR12
External IDsOMIM: 600876 MGI: 103077 HomoloGene: 80191 GeneCards: STX3
Orthologs
SpeciesHumanMouse
Entrez

6809

20908

Ensembl

ENSG00000166900

ENSMUSG00000041488

UniProt

Q13277

Q64704

RefSeq (mRNA)

NM_001178040
NM_004177

RefSeq (protein)

NP_001171511
NP_004168

NP_001020478
NP_001273472
NP_035632
NP_689344
NP_001347315

Location (UCSC)Chr 11: 59.71 – 59.81 MbChr 19: 11.75 – 11.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Syntaxin 3, also known as STX3, is a protein[5] which in humans is encoded by the STX3 gene.[6][7]

Function

The protein encoded by this gene is a member of the syntaxin family of cellular receptors for transport vesicles which participate in exocytosis in neutrophils.[6] STX3 has an important role in the growth of neurites and serves as a direct target for omega-6 arachidonic acid.[8] Mutations in Syntaxin 3 cause Microvillus inclusion disease.[9]

Interactions

Syntaxin 3 has been shown to interact with SNAP-25,[10][11][12] SNAP23[11][12][13][14] and SNAP29.[12]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166900 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041488 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ibaraki K, Horikawa HP, Morita T, Mori H, Sakimura K, Mishina M, Saisu H, Abe T (June 1995). "Identification of four different forms of syntaxin 3". Biochem. Biophys. Res. Commun. 211 (3): 997–1005. doi:10.1006/bbrc.1995.1910. PMID 7598732.
  6. ^ a b Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F (March 1999). "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1". J. Leukoc. Biol. 65 (3): 397–406. doi:10.1002/jlb.65.3.397. hdl:10261/59829. PMID 10080545. S2CID 18988377. Archived from the original on 2005-02-27. Retrieved 2008-08-13.
  7. ^ "Entrez Gene: STX3 syntaxin 3".
  8. ^ Darios F, Davletov B (April 2006). "Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3". Nature. 440 (7085): 813–7. Bibcode:2006Natur.440..813D. doi:10.1038/nature04598. PMID 16598260. S2CID 4411524.
  9. ^ Wiegerinck CL, Janecke AR, Schneeberger K, Vogel GF, van Haaften-Visser DY, Escher JC, Adam R, Thöni CE, Pfaller K, Jordan AJ, Weis CA, Nijman IJ, Monroe GR, van Hasselt PM, Cutz E, Klumperman J, Clevers H, Nieuwenhuis EE, Houwen RH, van Haaften G, Hess MW, Huber LA, Stapelbroek JM, Müller T, Middendorp S (2014). "Loss of syntaxin 3 causes variant microvillus inclusion disease". Gastroenterology. 147 (1): 65–68.e10. doi:10.1053/j.gastro.2014.04.002. PMID 24726755.
  10. ^ Hata Y, Südhof TC (Jun 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. PMID 7768895.
  11. ^ a b Ravichandran V, Chawla A, Roche PA (Jun 1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". J. Biol. Chem. 271 (23): 13300–3. doi:10.1074/jbc.271.23.13300. PMID 8663154.
  12. ^ a b c Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (Dec 1998). "Three novel proteins of the syntaxin/SNAP-25 family". J. Biol. Chem. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.
  13. ^ Imai A, Nashida T, Yoshie S, Shimomura H (Aug 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Arch. Oral Biol. 48 (8): 597–604. doi:10.1016/S0003-9969(03)00116-X. PMID 12828989.
  14. ^ Araki S, Tamori Y, Kawanishi M, Shinoda H, Masugi J, Mori H, Niki T, Okazawa H, Kubota T, Kasuga M (May 1997). "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochem. Biophys. Res. Commun. 234 (1): 257–62. doi:10.1006/bbrc.1997.6560. hdl:20.500.14094/D2002245. PMID 9168999.

Further reading

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