T-1152
Names
Other names
  • TL-1178
  • Stedman's meta compound
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C11H16N2O2.HI/c1-12-11(14)15-10-7-5-6-9(8-10)13(2,3)4;/h5-8H,1-4H3;1H
    Key: MIAARRZWMRMHIS-UHFFFAOYSA-N
  • CNC(=O)OC1=CC=CC(=C1)[N+](C)(C)C.[I-]
Hazards
Lethal dose or concentration (LD, LC):
270 μg/kg (subcutaneous, mice)[1]
115 μg/kg (intravenous, mice)[1]
260 μg/kg (subcutaneous, rabbits)[1]
2.5 mg/kg (oral, mice)[2]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

T-1152 is a quaternary carbamate anticholinesterase. It is synthesized by reaction of m-dimethylaminophenol with methyl isocyanate, followed by quaternization with methyl iodide.[3] Since T-1152 is toxic by ingestion, it was patented as a rodenticide in 1932.[2]

The chloride and methylsulfate salt of T-1152 is T-1690 (TL-1226) and AR-13, respectively.[1]

See also

References

  1. ^ a b c d Chemical Warfare Agents, and Related Chemical Problems. Parts I-II.
  2. ^ a b "Product for destroying animals".
  3. ^ Stedman, Edgar (1 January 1926). "Studies on the Relationship between Chemical Constitution and Physiological Action". Biochemical Journal. 20 (4): 719–734. doi:10.1042/bj0200719. PMC 1251776. PMID 16743713.
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