TACC1
Identifiers
AliasesTACC1, Ga55, transforming acidic coiled-coil containing protein 1
External IDsOMIM: 605301 MGI: 2443510 HomoloGene: 4575 GeneCards: TACC1
Orthologs
SpeciesHumanMouse
Entrez

6867

320165

Ensembl

ENSG00000147526

ENSMUSG00000065954

UniProt

O75410

Q6Y685

RefSeq (mRNA)

NM_001122824
NM_001146216
NM_006283
NM_001330521

NM_177089
NM_199323

RefSeq (protein)

NP_796063
NP_955355
NP_001389770
NP_001389771
NP_001389772

Location (UCSC)n/aChr 8: 25.64 – 25.75 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Transforming acidic coiled-coil-containing protein 1 is a protein that in humans is encoded by the TACC1 gene.[4]

Function

The function of this gene has not yet been determined; however, it is speculated that it may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers.[4]

Interactions

TACC1 has been shown to interact with:

References

  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000065954 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ a b "Entrez Gene: TACC1 transforming, acidic coiled-coil containing protein 1".
  5. ^ a b Delaval B, Ferrand A, Conte N, Larroque C, Hernandez-Verdun D, Prigent C, Birnbaum D (Jun 2004). "Aurora B -TACC1 protein complex in cytokinesis". Oncogene. 23 (26): 4516–22. doi:10.1038/sj.onc.1207593. PMID 15064709. S2CID 23605902.
  6. ^ a b c d Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251. S2CID 10536264.
  7. ^ Ryser S, Dizin E, Jefford CE, Delaval B, Gagos S, Christodoulidou A, Krause KH, Birnbaum D, Irminger-Finger I (Feb 2009). "Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2". Cancer Res. 69 (3): 1125–34. doi:10.1158/0008-5472.CAN-08-2134. PMID 19176389.
  8. ^ Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH (Apr 2002). "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells". Biochem. J. 363 (Pt 1): 195–200. doi:10.1042/0264-6021:3630195. PMC 1222467. PMID 11903063.
  9. ^ a b Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D (Aug 2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators". Oncogene. 21 (36): 5619–30. doi:10.1038/sj.onc.1205658. PMID 12165861.

Further reading


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