TAS2R31
Identifiers
AliasesTAS2R31, T2R31, T2R44, T2R53, TAS2R44, taste 2 receptor member 31
External IDsOMIM: 612669 MGI: 2681304 HomoloGene: 136304 GeneCards: TAS2R31
Orthologs
SpeciesHumanMouse
Entrez

259290

353165

Ensembl

ENSG00000256436
ENSG00000263097
ENSG00000282256

ENSMUSG00000053217

UniProt

P59538

Q7TQA8

RefSeq (mRNA)

NM_176885

NM_181276

RefSeq (protein)

NP_795366

NP_851793

Location (UCSC)Chr 12: 11.03 – 11.03 MbChr 6: 132.75 – 132.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Taste receptor, type 2, member 31, also known as TAS2R31, is a protein which in humans is encoded by the TAS2R31 gene.[5] This bitter taste receptor has been shown to respond to saccharin in vitro.[6]

TAS2R31 is also expressed in the smooth muscle of human airways, along with several other bitter taste receptors. Their activation in these cells causes an increase in intracellular calcium ion, which in turn triggers the opening of potassium channels which hyperpolarize the membrane and cause the smooth muscle to relax. Hence, activation of these receptors leads to bronchodilation.[7]

Polymorphisms in this gene have been associated with the perceived bitterness of sweetener acesulfame potassium.[8]

See also

References

  1. ^ a b c ENSG00000263097, ENSG00000282256 GRCh38: Ensembl release 89: ENSG00000256436, ENSG00000263097, ENSG00000282256 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053217 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: TAS2R31 taste receptor, type 2, member 31".
  6. ^ Kuhn C, Bufe B, Winnig M, Hofmann T, Frank O, Behrens M, Lewtschenko T, Slack JP, Ward CD, Meyerhof W (November 2004). "Bitter taste receptors for saccharin and acesulfame K". J. Neurosci. 24 (45): 10260–5. doi:10.1523/JNEUROSCI.1225-04.2004. PMC 6730199. PMID 15537898.
  7. ^ Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB (November 2010). "Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction". Nat. Med. 16 (11): 1299–304. doi:10.1038/nm.2237. PMC 3066567. PMID 20972434.
  8. ^ Allen AL, McGeary JE, Knopik VS, Hayes JE (2013). "Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31". Chem. Senses. 38 (5): 379–89. doi:10.1093/chemse/bjt017. PMC 3657735. PMID 23599216.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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