TAS2R4
Identifiers
Aliases	TAS2R4, T2R4, taste 2 receptor member 4
External IDs	OMIM: 604869 MGI: 2681210 HomoloGene: 49480 GeneCards: TAS2R4
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q34 Start 141,776,674 bp[1] End 141,781,691 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B1 Start 40,470,463 bp[2] End 40,471,475 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve cerebellar hemisphere right uterine tube nucleus accumbens Brodmann area 9 Achilles tendon prefrontal cortex caudate nucleus putamen ganglionic eminence n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity taste receptor activity bitter taste receptor activity signal transducer activity Cellular component plasma membrane cell projection cilium ciliary membrane membrane integral component of membrane Biological process response to stimulus detection of chemical stimulus involved in sensory perception of bitter taste sensory perception of taste respiratory gaseous exchange by respiratory system signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50832 57253 Ensembl ENSG00000127364 ENSMUSG00000037140 UniProt Q9NYW5 Q9JKT3 RefSeq (mRNA) NM_016944 NM_020502 RefSeq (protein) NP_058640 NP_065248 Location (UCSC) Chr 7: 141.78 – 141.78 Mb Chr 6: 40.47 – 40.47 Mb PubMed search [3] [4]
Wikidata
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Taste receptor type 2 member 4 is a protein that in humans is encoded by the TAS2R4 gene.^[5][6][7]

Function

This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception.^[7] The geographic distribution of TAS2R4 and TAS2R5 missense allele variants which prevent expression of the receptors is aligned with the distributions of tannin sorghum and the destructive agricultural bird pest in Africa, indicating the role of human taste in developing agroecosystems fitting local environments.^[8]

Ligands

Ligands listed in BitterDB include quinine, parthenolide, denatonium, some non-sugar sweeteners including sucralose and stevioside, and several oligopeptides.^[9]