TAS2R8
Identifiers
Aliases	TAS2R8, T2R8, TRB5, taste 2 receptor member 8
External IDs	OMIM: 604794 HomoloGene: 88894 GeneCards: TAS2R8
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.2 Start 10,806,051 bp[1] End 10,807,286 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex duodenum islet of Langerhans right adrenal gland gallbladder n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity taste receptor activity bitter taste receptor activity Cellular component plasma membrane membrane integral component of membrane Biological process detection of chemical stimulus involved in sensory perception of bitter taste signal transduction response to stimulus sensory perception of taste G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50836 n/a Ensembl ENSG00000277316 ENSG00000121314 ENSG00000272712 n/a UniProt Q9NYW2 n/a RefSeq (mRNA) NM_023918 n/a RefSeq (protein) NP_076407 n/a Location (UCSC) Chr 12: 10.81 – 10.81 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Taste receptor type 2 member 8 is a protein that in humans is encoded by the TAS2R8 gene.^[3][4][5]

Function

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.^[5]