TEAD4
Identifiers
Aliases	TEAD4, EFTR-2, RTEF1, TCF13L1, TEF-3, TEF3, TEFR-1, hRTEF-1B, TEA domain transcription factor 4
External IDs	OMIM: 601714 MGI: 106907 HomoloGene: 74463 GeneCards: TEAD4
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.33 Start 2,959,330 bp[1] End 3,040,676 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F3|6 62.92 cM Start 128,201,251 bp[2] End 128,277,786 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle triceps brachii muscle tibialis anterior muscle quadriceps femoris muscle skeletal muscle tissue vastus lateralis muscle body of pancreas biceps brachii thoracic diaphragm deltoid muscle Top expressed in morula yolk sac entorhinal cortex esophagus lip Purkinje cell extraocular muscle temporal muscle soleus muscle tracheobronchial tree More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm transcription regulator complex nucleus Biological process regulation of transcription by RNA polymerase II skeletal system development muscle organ development transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated hippo signaling transcription, DNA-templated positive regulation of transcription by RNA polymerase II embryonic organ development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7004 21679 Ensembl ENSG00000197905 ENSMUSG00000030353 UniProt Q15561 Q62296 RefSeq (mRNA) NM_201443 NM_003213 NM_201441 NM_001080979 NM_011567 RefSeq (protein) NP_003204 NP_958849 NP_958851 NP_001074448 NP_035697 Location (UCSC) Chr 12: 2.96 – 3.04 Mb Chr 6: 128.2 – 128.28 Mb PubMed search [3] [4]
Wikidata
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Transcriptional enhancer factor TEF-3 is a protein that in humans is encoded by the TEAD4 gene.^[5][6][7]

Function

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain.^[8] Members of the family in mammals are TEAD1, TEAD2, TEAD3, TEAD4. TEAD4 is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene.^[7] Gene ablation experiments in mice (i.e. knockout mice) showed that TEAD4 is essential for the formation of blastocysts during preimplantation embryo development.^[9][10] Although it was originally hypothesized to be essential for specification of trophectoderm lineage, it was later shown that functional trophectoderm can be produced leading to formation of blastocysts under in vitro conditions that suppress oxidative stress.^[11] Transcriptional coregulators, such as WWTR1 (TAZ) bind to members in this transcription factor family.