TECTA
Identifiers
Aliases	TECTA, DFNA12, DFNA8, DFNB21, tectorin alpha
External IDs	OMIM: 602574 MGI: 109575 HomoloGene: 3955 GeneCards: TECTA
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 121,101,243 bp[1] End 121,191,490 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.1|9 23.63 cM Start 42,240,915 bp[2] End 42,311,225 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte parietal lobe postcentral gyrus superior frontal gyrus superior vestibular nucleus pons Brodmann area 23 ganglionic eminence putamen Top expressed in utricle saccule petrous part of the temporal bone cochlea entorhinal cortex soleus muscle gastrocnemius muscle retina muscle tissue striated muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function extracellular matrix structural constituent Cellular component anchored component of membrane extracellular exosome membrane extracellular region plasma membrane extracellular matrix collagen-containing extracellular matrix Biological process cell-matrix adhesion sensory perception of sound C-terminal protein lipidation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7007 21683 Ensembl ENSG00000109927 ENSMUSG00000037705 UniProt O75443 O08523 RefSeq (mRNA) NM_005422 NM_009347 NM_001324548 NM_001378602 RefSeq (protein) NP_005413 NP_001311477 NP_033373 NP_001365531 Location (UCSC) Chr 11: 121.1 – 121.19 Mb Chr 9: 42.24 – 42.31 Mb PubMed search [3] [4]
Wikidata
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Alpha-tectorin is a protein that in humans is encoded by the TECTA gene.^[5][6][7]

The tectorial membrane is an apical extracellular matrix (aECM) of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness.^[7]