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The TIGER domain is a minor membraneless organelle in which messenger RNA (mRNA) encodes certain types of proteins to find the appropriate environment for growth. It is closely associated with the endoplasmic reticulum during protein synthesis. The TIGER domain was first documented by cell biologists Christine Mayr and Weirui Ma at the Gerstner Sloan Kettering Graduate School of Biomedical Sciences in 2018.[1][2][3][4][5][6]

The letters TIG stand for TIS granules and letters ER stands for the endoplasmic reticulum. TIS granules form a network of interconnected proteins that bind RNA and the endoplasmic reticulum is where protein synthesis occurs. This combination of the TIS proteins and the endoplasmic reticulum creates a distinct place in which mRNA and proteins collect, interact, and grow. The striped pattern of the TIS granules that are interweaving with the endoplasmic reticulum also resemble the orange and black stripes of a tiger. The TIGER domain has been found in all types of cells scientists have looked at so far.[1][2][3][4][5][6]

References

  1. ^ a b Ma, Weiru; Mayr, Christine (November 15, 2018). "A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3′UTR-Mediated Protein-Protein Interactions". Cell. Cell Press. 175 (6): 1492–1506.e19. doi:10.1016/j.cell.2018.10.007. PMC 6711188. PMID 30449617.
  2. ^ a b "A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3′UTR-Mediated Protein-Protein Interactions". ScienceDirect. November 15, 2018. Retrieved November 21, 2018.
  3. ^ a b Otto, Grant (November 27, 2018). "Protein trafficking through TIGER domains". Nature Reviews Molecular Cell Biology. 20 (1): 3. doi:10.1038/s41580-018-0088-9. PMID 30479375.
  4. ^ a b Tontonoz, Matthew (November 15, 2018). "This Newly Discovered Organelle Is Fierce". Memorial Sloan Kettering Cancer Center. Retrieved November 21, 2018.
  5. ^ a b "The Christine Mayr Lab". Gerstner Sloan Kettering Graduate School of Biomedical Sciences. Retrieved November 21, 2018.
  6. ^ a b "Christine Mayr: Overview". Gerstner Sloan Kettering Graduate School of Biomedical Sciences. Retrieved November 21, 2018.

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