TM4SF5
Identifiers
AliasesTM4SF5, transmembrane 4 L six family member 5
External IDsOMIM: 604657 MGI: 1922854 HomoloGene: 2947 GeneCards: TM4SF5
Orthologs
SpeciesHumanMouse
Entrez

9032

75604

Ensembl

ENSG00000142484

ENSMUSG00000018919

UniProt

O14894

n/a

RefSeq (mRNA)

NM_003963

NM_029360

RefSeq (protein)

NP_003954

n/a

Location (UCSC)Chr 17: 4.77 – 4.78 MbChr 11: 70.4 – 70.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene.[5][6]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000142484 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018919 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Muller-Pillasch F, Wallrapp C, Lacher U, Friess H, Buchler M, Adler G, Gress TM (Mar 1998). "Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer". Gene. 208 (1): 25–30. doi:10.1016/S0378-1119(97)00633-1. PMID 9479038.
  6. ^ a b "Entrez Gene: TM4SF5 transmembrane 4 L six family member 5".

Further reading


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