TOB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D5R, 2Z15, 5CI8, 5CI9
Identifiers
Aliases	TOB1, APRO6, PIG49, TOB, TROB, TROB1, transducer of ERBB2, 1, APRO5
External IDs	OMIM: 605523 MGI: 1349721 HomoloGene: 31334 GeneCards: TOB1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.33 Start 50,862,223 bp[1] End 50,867,978 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 94,102,280 bp[2] End 94,106,321 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium seminal vesicula trachea vastus lateralis muscle cardia human penis amniotic fluid urethra triceps brachii muscle jejunum Top expressed in extensor digitorum longus muscle plantaris muscle pineal gland submandibular gland parotid gland seminal vesicula intercostal muscle triceps brachii muscle digastric muscle sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function receptor tyrosine kinase binding SMAD binding protein binding transcription corepressor activity Cellular component CCR4-NOT complex cytoplasm nucleus Biological process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay negative regulation of osteoblast differentiation negative regulation of nuclear-transcribed mRNA poly(A) tail shortening negative regulation of nucleic acid-templated transcription negative regulation of BMP signaling pathway negative regulation of translation positive regulation of nuclear-transcribed mRNA poly(A) tail shortening BMP signaling pathway negative regulation of cell population proliferation positive regulation of signal transduction regulation of SMAD protein signal transduction regulation of gene expression Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10140 22057 Ensembl ENSG00000141232 ENSMUSG00000037573 UniProt P50616 Q61471 RefSeq (mRNA) NM_005749 NM_001243877 NM_001243885 NM_009427 RefSeq (protein) NP_001230806 NP_001230814 NP_005740 NP_033453 Location (UCSC) Chr 17: 50.86 – 50.87 Mb Chr 11: 94.1 – 94.11 Mb PubMed search [3] [4]
Wikidata
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Protein Tob1 is a protein that in humans is encoded by the TOB1 gene.^[5][6][7]

Function

This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein suppresses cell growth in tissue culture. The protein undergoes phosphorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.^[7]

Interactions

TOB1 has been shown to interact with:

• CNOT7,^[8][9]
• MAPK1^[10]
• MARCKS,^[11]
• Mitogen-activated protein kinase 9,^[10] and
• RPS6KA1.^[12]