TPCN2
Identifiers
AliasesTPCN2, SHEP10, TPC2, two pore segment channel 2
External IDsOMIM: 612163 MGI: 2385297 HomoloGene: 16375 GeneCards: TPCN2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_139075

NM_146206

RefSeq (protein)

NP_620714

NP_666318

Location (UCSC)Chr 11: 69.05 – 69.14 MbChr 7: 145.19 – 145.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Two pore segment channel 2 (TPC2) is a protein which in humans is encoded by the TPCN2 gene.[5] TPC2 is an ion channel, however, in contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domain (each containing segments S1 to S6).[6]

Structure

TPC2 is homologous to TPC1, the best characterized member of the TPC family. The structure of a TPC1 ortholog from Arabidopsis thaliana has been solved by two laboratories.[7][8] The structures were solved using X-ray crystallography and contained the fold of a voltage-gated ion channel and EF hands.

Filoviral Infections

Genetic knockout and pharmacological inhibition experiments demonstrate that Two-pore Channels, TPC1 and TPC2, are required for infection by Filoviruses Ebola and Marburg in mice.[9]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162341 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048677 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: two pore segment channel 2".
  6. ^ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacological Reviews. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. S2CID 35096827.
  7. ^ Guo J, Zeng W, Chen Q, Lee C, Chen L, Yang Y, Cang C, Ren D, Jiang Y (March 2016). "Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana". Nature. 531 (7593): 196–201. doi:10.1038/nature16446. PMC 4841471. PMID 26689363.
  8. ^ Kintzer AF, Stroud RM (March 2016). "Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana". Nature. 531 (7593): 258–62. doi:10.1038/nature17194. PMC 4863712. PMID 26961658.
  9. ^ Sakurai Y, Kolokoltsov AA, Chen CC, Tidwell MW, Bauta WE, Klugbauer N, Grimm C, Wahl-Schott C, Biel M, Davey RA (February 2015). "Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment". Science. 347 (6225): 995–8. doi:10.1126/science.1258758. PMC 4550587. PMID 25722412.

Further reading