TRAF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTRAF2, MGC:45012, TRAP, TRAP3, TNF receptor associated factor 2, RNF117
External IDsOMIM: 601895 MGI: 101835 HomoloGene: 22520 GeneCards: TRAF2
Orthologs
SpeciesHumanMouse
Entrez

7186

22030

Ensembl

ENSG00000127191

ENSMUSG00000026942

UniProt

Q12933

P39429

RefSeq (mRNA)

NM_021138

NM_009422
NM_001290413

RefSeq (protein)

NP_066961

NP_001277342
NP_033448

Location (UCSC)Chr 9: 136.88 – 136.93 MbChr 2: 25.41 – 25.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TNF receptor-associated factor 2 is a protein that in humans is encoded by the TRAF2 gene.[5]

Function

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms complexes with other TRAF proteins. TRAF2 is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-κB. The protein complex formed by TRAF2 and TRAF1 interacts with the IAP family members cIAP1 and cIAP2, and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. cIAP1 can ubiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.[6]

Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps

Interactions

TRAF2 has been shown to interact with:

References

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