TRAPPC2
Identifiers
Aliases	TRAPPC2, MIP2A, SEDL, SEDT, TRAPPC2P1, TRS20, ZNF547L, hYP38334, trafficking protein particle complex 2, trafficking protein particle complex subunit 2
External IDs	OMIM: 300202 MGI: 1913476 HomoloGene: 5436 GeneCards: TRAPPC2
Gene location (Mouse) Chr. X chromosome (mouse)[1] Band X|X F5 Start 165,223,570 bp[1] End 165,236,136 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis cerebellar hemisphere thymus ganglionic eminence blood lymph node superficial temporal artery urethra endometrium dorsolateral prefrontal cortex Top expressed in quadriceps femoris muscle hippocampus proper neural tube mesencephalon superior frontal gyrus secondary oocyte hypothalamus cerebellar cortex muscle tissue skeletal muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane transporter binding transcription factor binding protein binding Cellular component cytoplasm cytosol intracellular anatomical structure perinuclear region of cytoplasm Golgi membrane nucleus nucleoplasm endoplasmic reticulum endoplasmic reticulum-Golgi intermediate compartment intracellular membrane-bounded organelle TRAPP complex Biological process skeletal system development regulation of transcription, DNA-templated transcription, DNA-templated COPII vesicle coating vesicle-mediated transport endoplasmic reticulum to Golgi vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6399 66226 Ensembl ENSG00000196459 ENSMUSG00000079317 UniProt P0DI81 P0DI82 Q9CQP2 RefSeq (mRNA) NM_001011658 NM_001128835 NM_014563 NM_025432 NM_001313722 RefSeq (protein) NP_001011658 NP_001122307 NP_055378 NP_001011658.1 NP_055378.1 NP_001300651 NP_079708 NP_079595 Location (UCSC) n/a Chr X: 165.22 – 165.24 Mb PubMed search [2] [3]
Wikidata
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Trafficking protein particle complex subunit 2 (TRAPPC2) also known as MBP-1-interacting protein 2A (MIP-2A) is a protein that in humans is encoded by the TRAPPC2 gene.^[4][5] A processed pseudogene of this gene is located on chromosome 19, and other pseuodogenes of it are found on chromosome 8 and the Y chromosome. Two transcript variants encoding the same protein have been found for this gene.^[5]

Function

Trafficking protein particle complex subunit 2 is thought to be part of a large multisubunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind MBP1 and block its transcriptional repression capability.^[5]

Genetic Location

The TRAPPC2 gene is located on the X-chromosome at position 22 between base-pairs 13,712,241 to 13,734,634.^[6]

Clinical significance

Mutations in this gene are a cause of X-linked spondyloepiphyseal dysplasia tarda (SEDT).^[5]

Interactions

TRAPPC2 has been shown to interact with Alpha-enolase^[7] and CLIC1.^[8]