TRIB3
Identifiers
Aliases	TRIB3, C20orf97, NIPK, SINK, SKIP3, TRB3, tribbles pseudokinase 3
External IDs	OMIM: 607898 MGI: 1345675 HomoloGene: 10902 GeneCards: TRIB3
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 362,835 bp[1] End 397,559 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 G3|2 74.83 cM Start 152,179,342 bp[2] End 152,185,952 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver pancreatic ductal cell islet of Langerhans stromal cell of endometrium upper lobe of left lung optic nerve body of pancreas parotid gland anterior pituitary skin of abdomen Top expressed in calvaria yolk sac submandibular gland seminal vesicula ascending aorta semi-lunar valve aortic valve olfactory epithelium morula lacrimal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription corepressor activity ubiquitin-protein transferase regulator activity protein kinase inhibitor activity kinase activity protein binding mitogen-activated protein kinase kinase binding ATP binding protein kinase binding ubiquitin protein ligase binding Cellular component cytosol plasma membrane nucleus Biological process negative regulation of fat cell differentiation regulation of transcription, DNA-templated negative regulation of fatty acid biosynthetic process negative regulation of protein kinase activity negative regulation of transcription by RNA polymerase II transcription, DNA-templated response to endoplasmic reticulum stress protein phosphorylation intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress positive regulation of ubiquitin-protein transferase activity cellular response to insulin stimulus regulation of MAP kinase activity positive regulation of protein binding negative regulation of transcription, DNA-templated regulation of glucose transmembrane transport positive regulation of proteasomal ubiquitin-dependent protein catabolic process apoptotic process regulation of lipid metabolic process negative regulation of protein kinase B signaling regulation of autophagy Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57761 228775 Ensembl ENSG00000101255 ENSMUSG00000032715 UniProt Q96RU7 Q8K4K2 RefSeq (mRNA) NM_021158 NM_001301188 NM_001301190 NM_001301193 NM_001301196 NM_001301201 NM_144554 NM_175093 RefSeq (protein) NP_001288117 NP_001288119 NP_001288122 NP_001288125 NP_001288130 NP_066981 NP_780302 Location (UCSC) Chr 20: 0.36 – 0.4 Mb Chr 2: 152.18 – 152.19 Mb PubMed search [3] [4]
Wikidata
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Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene.^[5][6][7]

Function

The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. It is a pseudoenzyme that is thought to be a negative regulator of NF-kappaB, and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein has been reported to negatively regulate the cell survival serine-threonine kinase AKT1.^[7] TRIB3 has recently been associated with neuronal signalling, and like TRIB1 and TRIB2, could be considered as a potential allosteric drug target ^[8][9]

Interactions

TRIB3 has been shown to interact with:

• AKT1,^[5]
• CSNK2B,^[10]
• Fibronectin^[10]
• MCM3AP,^[11]
• RELA,^[12]
• SIAH1,^[10] and
• TIAF1.^[10]