TRIM24
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YYN, 3O33, 3O34, 3O35, 3O36, 3O37, 4YAB, 4YAD, 4YAT, 4YAX, 4YBM, 4YBS, 4YBT, 4YC9, 4ZQL
Identifiers
Aliases	TRIM24, PTC6, RNF82, TF1A, TIF1, TIF1A, TIF1ALPHA, hTIF1, tripartite motif containing 24
External IDs	OMIM: 603406 MGI: 109275 HomoloGene: 20830 GeneCards: TRIM24
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q33-q34 Start 138,460,259 bp[1] End 138,589,996 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B1 Start 37,847,746 bp[2] End 37,943,231 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm ganglionic eminence parotid gland left adrenal gland endothelial cell pancreatic epithelial cell jejunum visceral pleura jejunal mucosa liver Top expressed in secondary oocyte spermatid spermatocyte seminiferous tubule lacrimal gland parotid gland sternocleidomastoid muscle triceps brachii muscle maxillary prominence abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase activity sequence-specific DNA binding DNA binding ubiquitin protein ligase activity transcription coactivator activity zinc ion binding p53 binding chromatin binding metal ion binding ubiquitin-protein transferase activity methylated histone binding estrogen response element binding protein binding nuclear receptor binding lysine-acetylated histone binding signaling receptor binding protein tyrosine kinase activity transferase activity Cellular component cytoplasm cytosol intracellular anatomical structure perichromatin fibrils nucleus nucleoplasm Biological process regulation of apoptotic process regulation of transcription, DNA-templated regulation of protein stability calcium ion homeostasis regulation of signal transduction by p53 class mediator regulation of vitamin D receptor signaling pathway transcription by RNA polymerase II transcription, DNA-templated cellular response to estrogen stimulus positive regulation of transcription, DNA-templated protein phosphorylation positive regulation of gene expression protein catabolic process protein ubiquitination protein autophosphorylation negative regulation of transcription, DNA-templated negative regulation of cell population proliferation peptidyl-tyrosine phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8805 21848 Ensembl ENSG00000122779 ENSMUSG00000029833 UniProt O15164 Q64127 RefSeq (mRNA) NM_003852 NM_015905 NM_001272064 NM_001272076 NM_145076 RefSeq (protein) NP_003843 NP_056989 NP_001258993 NP_001259005 NP_659542 Location (UCSC) Chr 7: 138.46 – 138.59 Mb Chr 6: 37.85 – 37.94 Mb PubMed search [3] [4]
Wikidata
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Tripartite motif-containing 24 (TRIM24) also known as transcriptional intermediary factor 1α (TIF1α) is a protein that, in humans, is encoded by the TRIM24 gene.^[5][6][7]

Function

The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D₃ receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains – a RING, a B-box type 1 and a B-box type 2 – and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.^[5]

Interactions

TRIM24 has been shown to interact with Mineralocorticoid receptor,^[6][8] TRIM33,^[9] Estrogen receptor alpha^[6][10] and Retinoid X receptor alpha.^[6][11]