TRIO
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NTY, 2NZ8
Identifiers
Aliases	TRIO, ARHGEF23, tgat, trio Rho guanine nucleotide exchange factor, MEBAS, MRD44, MRD63, TRIO gene
External IDs	OMIM: 601893 MGI: 1927230 HomoloGene: 20847 GeneCards: TRIO
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p15.2 Start 14,143,342 bp[1] End 14,532,128 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 B1 Start 27,730,737 bp[2] End 28,025,934 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve stromal cell of endometrium gastric mucosa ganglionic eminence Achilles tendon ascending aorta transverse colon left coronary artery upper lobe of left lung gallbladder Top expressed in superior frontal gyrus cerebellar cortex internal carotid artery lateral geniculate nucleus ventromedial nucleus external carotid artery olfactory bulb cerebellar vermis subiculum vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity guanyl-nucleotide exchange factor activity kinase activity protein serine/threonine kinase activity protein binding ATP binding Cellular component cytoplasm cytosol Biological process phosphorylation protein phosphorylation transmembrane receptor protein tyrosine phosphatase signaling pathway positive regulation of apoptotic process regulation of Rho protein signal transduction regulation of small GTPase mediated signal transduction negative regulation of fat cell differentiation G protein-coupled receptor signaling pathway axon guidance central nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7204 223435 Ensembl ENSG00000038382 ENSMUSG00000022263 UniProt O75962 Q0KL02 RefSeq (mRNA) NM_007118 NM_001081302 RefSeq (protein) NP_009049 NP_001074771 Location (UCSC) Chr 5: 14.14 – 14.53 Mb Chr 15: 27.73 – 28.03 Mb PubMed search [3] [4]
Wikidata
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Triple functional domain protein is a protein that in humans is encoded by the TRIO gene.^[5][6]

Interactions

TRIO (gene) has been shown to interact with Filamin^[7] and RHOA.^[8]