TSPAN32
Identifiers
Aliases	TSPAN32, ART1, PHEMX, PHMX, TSSC6, tetraspanin 32
External IDs	OMIM: 603853 MGI: 1350360 HomoloGene: 10650 GeneCards: TSPAN32
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 2,301,997 bp[1] End 2,318,204 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F5|7 88.09 cM Start 142,558,783 bp[2] End 142,573,381 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood spleen bone marrow cells left ventricle lymph node spongy bone upper lobe of left lung appendix gallbladder Top expressed in blood spleen thymus bone marrow yolk sac subcutaneous adipose tissue ankle joint artery dermis carotid body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function molecular function Cellular component integral component of membrane cell surface integrin alphaIIb-beta3 complex integral component of plasma membrane intracellular anatomical structure membrane Biological process hemostasis integrin-mediated signaling pathway negative regulation of myeloid dendritic cell activation cell-cell signaling cell surface receptor signaling pathway regulation of defense response to virus platelet aggregation blood coagulation cytoskeleton organization negative regulation of cell population proliferation defense response to protozoan Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10077 27027 Ensembl ENSG00000064201 ENSMUSG00000000244 UniProt Q96QS1 Q9JHH2 RefSeq (mRNA) NM_005705 NM_139022 NM_139024 NM_001128080 NM_001128081 NM_001128082 NM_020286 RefSeq (protein) NP_620591 NP_001121552 NP_001121553 NP_001121554 NP_064682 Location (UCSC) Chr 11: 2.3 – 2.32 Mb Chr 7: 142.56 – 142.57 Mb PubMed search [3] [4]
Wikidata
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Tetraspanin-32 is a protein that in humans is encoded by the TSPAN32 gene.^[5][6][7]

Function

This gene is described as a member of the tetraspanin superfamily whose expression is confined to hematopoietic tissues.^[7]

Clinical significance

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4 (TSSC4), escapes imprinting. This gene may play a role in malignancies and disease that involve this region as well as hematopoietic cell function.^[7]