TSPAN8
Identifiers
AliasesTSPAN8, CO-029, TM4SF3, tetraspanin 8
External IDsOMIM: 600769 MGI: 2384918 HomoloGene: 20968 GeneCards: TSPAN8
Orthologs
SpeciesHumanMouse
Entrez

7103

216350

Ensembl

ENSG00000127324

ENSMUSG00000034127

UniProt

P19075

Q8R3G9

RefSeq (mRNA)

NM_004616
NM_001369760

NM_001168679
NM_001168680
NM_146010

RefSeq (protein)

NP_004607
NP_001356689

NP_001162150
NP_001162151
NP_666122

Location (UCSC)Chr 12: 71.13 – 71.44 MbChr 10: 115.65 – 115.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tetraspanin-8 is a protein that in humans is encoded by the TSPAN8 gene.[5][6]

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene.[6]

Clinical significance

Overall survival of ovarian cancer patients was effectively predicted by TSPAN8.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127324 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034127 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Szala S, Kasai Y, Steplewski Z, Rodeck U, Koprowski H, Linnenbach AJ (September 1990). "Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens". Proceedings of the National Academy of Sciences of the United States of America. 87 (17): 6833–7. Bibcode:1990PNAS...87.6833S. doi:10.1073/pnas.87.17.6833. PMC 54632. PMID 2395876.
  6. ^ a b "Entrez Gene: TSPAN8 tetraspanin 8".
  7. ^ Fekete T, Rásó E, Pete I, Tegze B, Liko I, Munkácsy G, Sipos N, Rigó J, Györffy B (July 2012). "Meta-analysis of gene expression profiles associated with histological classification and survival in 829 ovarian cancer samples" (PDF). International Journal of Cancer. 131 (1): 95–105. doi:10.1002/ijc.26364. PMID 21858809. S2CID 205944534.

Further reading

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