|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||310.441 g·mol−1|
|3D model (JSmol)|
Tabernanthine is an alkaloid found in Tabernanthe iboga.
It has been used in laboratory experiments to study how addiction affects the brain.
Tabernanthine persistently reduced the self-administration of cocaine and morphine in rats.
It is kappa opioid agonist (Ki = 0.15 μM) and NMDA receptor (Ki = 10.5 μM) antagonist. Compared to ibogaine, it binds weakly to σ1 and σ2 receptor.