The river is mentioned in "Tallahatchie River Blues," recorded by Mattie Delaney in 1930. This blues song laments the devastation caused in the local African-American community by a flood on the normally shallow river. The river is 50 ft (15 m) deep with very sharp rocks.
The river has historical significance due to the 1955 murder of Emmett Till, an African-American boy visiting from Chicago, who was brutally murdered by white men in Money, Mississippi, for allegedly whistling at a white woman. In 2017, Till's accuser, Carolyn Bryant Donham, spoke to Timothy B. Tyson, a Duke University professor who has written a book, “The Blood of Emmett Till." In it, he wrote that Donham said of her long-ago allegations that Till grabbed her and was menacing and sexually crude toward her, “that part is not true.” Till was beaten, shot, and sunk in the river with a cotton gin fan tied around his neck by barbed wire.
This event is mentioned in the song, "Freedom Highway" by The Staple Singers, in the lines, "Found dead people in the forests, Tallahatchie River and lakes... whole world is wondering, what's wrong with the United States?"[10] Till’s badly mutilated body was found near the river by two boys who were fishing.
The eponymous wooden bridge over the river was popularized in Bobbie Gentry's 1967 hit song "Ode to Billie Joe," which has the refrain, "Billie Joe McAllister jumped off the Tallahatchie bridge." A film was titled Ode to Billy Joe. The wooden bridge collapsed in 1972 after being set alight by vandals.[11] It crossed the Tallahatchie River at Money, about ten miles north of Greenwood, Mississippi. The bridge has since been replaced.
